Chromatin proteins involved in the initiation of DNA replication

Alison Rowles, J. Julian Blow

Research output: Contribution to journalArticlepeer-review


Eukaryotic DNA replication is regulated at least in part by the assembly of initiation proteins onto origins of replication. The origin recognition complex (ORC) is bound to origins throughout most of the cell cycle. Other initiation proteins, such as Cdc6 and the MCM/P1 proteins, are assembled onto ORC-containing chromatin during G1 to define a prereplicative complex. During S phase, these proteins are displaced from chromatin and their reassembly is inhibited by protein-dependent kinases.
Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number2
Publication statusPublished - Apr 1997

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