Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)

Joachim Arnemann, Nigel K Spurr, Grant N. Wheeler, Andrew E. Parker, Roger S. Buxton

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Abstract

We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).
Original languageEnglish
Pages (from-to)640-645
Number of pages6
JournalGenomics
Volume10
Issue number3
DOIs
Publication statusPublished - Jul 1991

Keywords

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 18
  • Chromosomes, Human, Pair 6
  • Chromosomes, Human, Pair 7
  • Chromosomes, Human, Pair 9
  • Cytoskeletal Proteins
  • Desmocollins
  • Desmogleins
  • Desmoplakins
  • Desmosomes
  • Genes
  • Humans
  • Hybrid Cells
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Rats
  • gamma Catenin

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