Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)

Joachim Arnemann; Nigel K Spurr; Grant N. Wheeler; Andrew E. Parker; Roger S. Buxton

doi:10.1016/0888-7543(91)90446-L

Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)

Joachim Arnemann, Nigel K Spurr, Grant N. Wheeler, Andrew E. Parker, Roger S. Buxton

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).

Original language	English
Pages (from-to)	640-645
Number of pages	6
Journal	Genomics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(91)90446-L
Publication status	Published - Jul 1991

Keywords

Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 9
Cytoskeletal Proteins
Desmocollins
Desmogleins
Desmoplakins
Desmosomes
Genes
Humans
Hybrid Cells
Mice
Molecular Sequence Data
Polymerase Chain Reaction
Rats
gamma Catenin

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10.1016/0888-7543(91)90446-L

Cite this

@article{13dd4f47488e4a1b8527a3471dbfa96d,

title = "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)",

abstract = "We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).",

keywords = "Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 18, Chromosomes, Human, Pair 6, Chromosomes, Human, Pair 7, Chromosomes, Human, Pair 9, Cytoskeletal Proteins, Desmocollins, Desmogleins, Desmoplakins, Desmosomes, Genes, Humans, Hybrid Cells, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Rats, gamma Catenin",

author = "Joachim Arnemann and Spurr, {Nigel K} and Wheeler, {Grant N.} and Parker, {Andrew E.} and Buxton, {Roger S.}",

year = "1991",

month = jul,

doi = "10.1016/0888-7543(91)90446-L",

language = "English",

volume = "10",

pages = "640--645",

journal = "Genomics",

issn = "1089-8646",

publisher = "Academic Press Inc.",

number = "3",

}

Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP). / Arnemann, Joachim; Spurr, Nigel K; Wheeler, Grant N. et al.
In: Genomics, Vol. 10, No. 3, 07.1991, p. 640-645.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)

AU - Arnemann, Joachim

AU - Spurr, Nigel K

AU - Wheeler, Grant N.

AU - Parker, Andrew E.

AU - Buxton, Roger S.

PY - 1991/7

Y1 - 1991/7

N2 - We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).

AB - We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction, the desmosomal cadherins DGI (desmoglein) and DGII/III (desmocollins), and the plaque proteins DPI/II (desmoplakin) and DPIII (plakoglobin) and used them to test human-mouse and human-rat somatic cell hybrids with different contents of human chromosomes. From these data we were able to assign DGI to chromosome 18 (DSG), DGII/III to chromosome 9p (DSC), DPI/II to chromosome 6p21-ter(DSP), and DPIII to chromosome 7 (JUP).

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KW - Base Sequence

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KW - Chromosomes, Human, Pair 6

KW - Chromosomes, Human, Pair 7

KW - Chromosomes, Human, Pair 9

KW - Cytoskeletal Proteins

KW - Desmocollins

KW - Desmogleins

KW - Desmoplakins

KW - Desmosomes

KW - Genes

KW - Humans

KW - Hybrid Cells

KW - Mice

KW - Molecular Sequence Data

KW - Polymerase Chain Reaction

KW - Rats

KW - gamma Catenin

U2 - 10.1016/0888-7543(91)90446-L

DO - 10.1016/0888-7543(91)90446-L

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