Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure

Angus K Nightingale, Jenifer G Crilley, Nicholas C Pegge, Ernie A Boehm, Catherine Mumford, Doris J Taylor, Peter Styles, Kieran Clarke, Michael P Frenneaux

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Chronic heart failure (CHF) is associated with abnormalities of skeletal muscle metabolism. This may be due to impaired oxygen delivery as a result of endothelial dysfunction.
Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalEuropean Journal of Heart Failure
Issue number3
Publication statusPublished - Mar 2007


  • Adenosine Triphosphate
  • Aged
  • Ascorbic Acid
  • Chronic Disease
  • Double-Blind Method
  • Endothelium, Vascular
  • Female
  • Great Britain
  • Heart Failure
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Muscle, Skeletal
  • Phosphocreatine

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