Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects

Anna R Proteggente, Cristina Rota, John Majewicz, Gerald Rimbach, Anne-Marie Minihane, Klaus Kraemer, John K Lodge

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We have compared the biokinetics of deuterated natural (RRR) and synthetic (all rac) alpha-tocopherol in male apoE4-carrying smokers and nonsmokers. In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout. Before and after each supplementation period subjects underwent a biokinetic protocol (48 h) with 150 mg deuterated RRR- or all rac-alpha-tocopheryl acetate. During the biokinetic protocols, the elimination of endogenous plasma alpha-tocopherol was significantly faster in smokers (P
Original languageEnglish
Pages (from-to)2080-2091
Number of pages12
JournalFree Radical Biology & Medicine
Issue number12
Publication statusPublished - 15 Jun 2006


  • Adult
  • Alzheimer Disease
  • Apolipoprotein E4
  • Apolipoproteins E
  • Ascorbic Acid
  • Chromans
  • Coronary Disease
  • F2-Isoprostanes
  • Genetic Predisposition to Disease
  • Humans
  • Hyperlipoproteinemia Type V
  • Male
  • Middle Aged
  • Smoking
  • Tocopherols
  • alpha-Tocopherol

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