Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects

Anna R Proteggente; Cristina Rota; John Majewicz; Gerald Rimbach; Anne-Marie Minihane; Klaus Kraemer; John K Lodge

doi:10.1016/j.freeradbiomed.2006.02.006

Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects

Anna R Proteggente, Cristina Rota, John Majewicz, Gerald Rimbach, Anne-Marie Minihane, Klaus Kraemer, John K Lodge

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We have compared the biokinetics of deuterated natural (RRR) and synthetic (all rac) alpha-tocopherol in male apoE4-carrying smokers and nonsmokers. In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout. Before and after each supplementation period subjects underwent a biokinetic protocol (48 h) with 150 mg deuterated RRR- or all rac-alpha-tocopheryl acetate. During the biokinetic protocols, the elimination of endogenous plasma alpha-tocopherol was significantly faster in smokers (P

Original language	English
Pages (from-to)	2080-2091
Number of pages	12
Journal	Free Radical Biology & Medicine
Volume	40
Issue number	12
DOIs	https://doi.org/10.1016/j.freeradbiomed.2006.02.006
Publication status	Published - 15 Jun 2006

Keywords

Adult
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Ascorbic Acid
Chromans
Coronary Disease
F2-Isoprostanes
Genetic Predisposition to Disease
Humans
Hyperlipoproteinemia Type V
Male
Middle Aged
Smoking
Tocopherols
alpha-Tocopherol

Access to Document

10.1016/j.freeradbiomed.2006.02.006

Cite this

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title = "Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects",

abstract = "We have compared the biokinetics of deuterated natural (RRR) and synthetic (all rac) alpha-tocopherol in male apoE4-carrying smokers and nonsmokers. In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout. Before and after each supplementation period subjects underwent a biokinetic protocol (48 h) with 150 mg deuterated RRR- or all rac-alpha-tocopheryl acetate. During the biokinetic protocols, the elimination of endogenous plasma alpha-tocopherol was significantly faster in smokers (P ",

keywords = "Adult, Alzheimer Disease, Apolipoprotein E4, Apolipoproteins E, Ascorbic Acid, Chromans, Coronary Disease, F2-Isoprostanes, Genetic Predisposition to Disease, Humans, Hyperlipoproteinemia Type V, Male, Middle Aged, Smoking, Tocopherols, alpha-Tocopherol",

author = "Proteggente, {Anna R} and Cristina Rota and John Majewicz and Gerald Rimbach and Anne-Marie Minihane and Klaus Kraemer and Lodge, {John K}",

year = "2006",

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T1 - Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) alpha-tocopherol: a biokinetic study in apoE4 male subjects

AU - Proteggente, Anna R

AU - Rota, Cristina

AU - Majewicz, John

AU - Rimbach, Gerald

AU - Minihane, Anne-Marie

AU - Kraemer, Klaus

AU - Lodge, John K

PY - 2006/6/15

Y1 - 2006/6/15

N2 - We have compared the biokinetics of deuterated natural (RRR) and synthetic (all rac) alpha-tocopherol in male apoE4-carrying smokers and nonsmokers. In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout. Before and after each supplementation period subjects underwent a biokinetic protocol (48 h) with 150 mg deuterated RRR- or all rac-alpha-tocopheryl acetate. During the biokinetic protocols, the elimination of endogenous plasma alpha-tocopherol was significantly faster in smokers (P

AB - We have compared the biokinetics of deuterated natural (RRR) and synthetic (all rac) alpha-tocopherol in male apoE4-carrying smokers and nonsmokers. In a randomized, crossover study subjects underwent two 4-week treatments (400 mg/day) with undeuterated RRR- and all rac-alpha-tocopheryl acetate around a 12-week washout. Before and after each supplementation period subjects underwent a biokinetic protocol (48 h) with 150 mg deuterated RRR- or all rac-alpha-tocopheryl acetate. During the biokinetic protocols, the elimination of endogenous plasma alpha-tocopherol was significantly faster in smokers (P

KW - Adult

KW - Alzheimer Disease

KW - Apolipoprotein E4

KW - Apolipoproteins E

KW - Ascorbic Acid

KW - Chromans

KW - Coronary Disease

KW - F2-Isoprostanes

KW - Genetic Predisposition to Disease

KW - Humans

KW - Hyperlipoproteinemia Type V

KW - Male

KW - Middle Aged

KW - Smoking

KW - Tocopherols

KW - alpha-Tocopherol

U2 - 10.1016/j.freeradbiomed.2006.02.006

DO - 10.1016/j.freeradbiomed.2006.02.006

M3 - Article

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VL - 40

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EP - 2091

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

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ER -