Ciprofloxacin resistance in Neisseria gonorrhoeae in England and Wales in 2002

Kevin A Fenton; Catherine Ison; Alan P Johnson; Elizabeth Rudd; Mehnam Soltani; Iona Martin; Tom Nichols; David M Livermore

doi:10.1016/S0140-6736(03)13489-7

Ciprofloxacin resistance in Neisseria gonorrhoeae in England and Wales in 2002

Kevin A Fenton, Catherine Ison, Alan P Johnson, Elizabeth Rudd, Mehnam Soltani, Iona Martin, Tom Nichols, David M Livermore

Norwich Medical School

Research output: Contribution to journal › Article

98 Citations (Scopus)

Abstract

The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) monitors trends in antimicrobial resistance in consecutive gonococcal isolates from 26 genitourinary medicine clinics in England and Wales. In 2002, 2204 gonococcal isolates were tested, and the overall prevalence of ciprofloxacin resistance (minimum inhibitory concentration ≥1 mg/L) was 9·8%, compared with 3·1% in 2001 and 21% in 2000. Between 2001 and 2002, prevalence of ciprofloxacin resistance increased two to three-fold, irrespective of recent sexual contact overseas, sex, or residence within or outside of London. These findings suggest that national and local treatment guidelines need to be reviewed urgently.

Original language	English
Pages (from-to)	1867-1869
Number of pages	3
Journal	The Lancet
Volume	361
Issue number	9372
DOIs	https://doi.org/10.1016/S0140-6736(03)13489-7
Publication status	Published - 31 May 2003

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10.1016/S0140-6736(03)13489-7

Cite this

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title = "Ciprofloxacin resistance in Neisseria gonorrhoeae in England and Wales in 2002",

abstract = "The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) monitors trends in antimicrobial resistance in consecutive gonococcal isolates from 26 genitourinary medicine clinics in England and Wales. In 2002, 2204 gonococcal isolates were tested, and the overall prevalence of ciprofloxacin resistance (minimum inhibitory concentration ≥1 mg/L) was 9·8%, compared with 3·1% in 2001 and 21% in 2000. Between 2001 and 2002, prevalence of ciprofloxacin resistance increased two to three-fold, irrespective of recent sexual contact overseas, sex, or residence within or outside of London. These findings suggest that national and local treatment guidelines need to be reviewed urgently.",

author = "Fenton, {Kevin A} and Catherine Ison and Johnson, {Alan P} and Elizabeth Rudd and Mehnam Soltani and Iona Martin and Tom Nichols and Livermore, {David M}",

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T1 - Ciprofloxacin resistance in Neisseria gonorrhoeae in England and Wales in 2002

AU - Fenton, Kevin A

AU - Ison, Catherine

AU - Johnson, Alan P

AU - Rudd, Elizabeth

AU - Soltani, Mehnam

AU - Martin, Iona

AU - Nichols, Tom

AU - Livermore, David M

PY - 2003/5/31

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N2 - The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) monitors trends in antimicrobial resistance in consecutive gonococcal isolates from 26 genitourinary medicine clinics in England and Wales. In 2002, 2204 gonococcal isolates were tested, and the overall prevalence of ciprofloxacin resistance (minimum inhibitory concentration ≥1 mg/L) was 9·8%, compared with 3·1% in 2001 and 21% in 2000. Between 2001 and 2002, prevalence of ciprofloxacin resistance increased two to three-fold, irrespective of recent sexual contact overseas, sex, or residence within or outside of London. These findings suggest that national and local treatment guidelines need to be reviewed urgently.

AB - The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) monitors trends in antimicrobial resistance in consecutive gonococcal isolates from 26 genitourinary medicine clinics in England and Wales. In 2002, 2204 gonococcal isolates were tested, and the overall prevalence of ciprofloxacin resistance (minimum inhibitory concentration ≥1 mg/L) was 9·8%, compared with 3·1% in 2001 and 21% in 2000. Between 2001 and 2002, prevalence of ciprofloxacin resistance increased two to three-fold, irrespective of recent sexual contact overseas, sex, or residence within or outside of London. These findings suggest that national and local treatment guidelines need to be reviewed urgently.

U2 - 10.1016/S0140-6736(03)13489-7

DO - 10.1016/S0140-6736(03)13489-7

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VL - 361

SP - 1867

EP - 1869

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9372

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