Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection

J Nunes, M Naymark, L Sauer, A Muhammad, H Keun, J Sturge, J Stebbing, J Waxman, D Pchejetski

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


Current markers available for screening normal populations and for monitoring prostate cancer (PCa) treatment lack sensitivity and selectivity. Sphingosine-1-phosphate (S1P) is a circulating lipid second messenger involved in cell growth and migration, the immune response, angiogenesis, and malignant transformation.
Original languageEnglish
Pages (from-to)909-915
Number of pages7
JournalBritish Journal of Cancer
Issue number5
Publication statusPublished - 28 Feb 2012


  • Anemia
  • Cell Line, Tumor
  • Disease Progression
  • Early Detection of Cancer
  • Erythrocytes
  • Humans
  • Lysophospholipids
  • Male
  • Phosphotransferases (Alcohol Group Acceptor)
  • Prognosis
  • Prostate-Specific Antigen
  • Prostatic Neoplasms
  • Sphingosine
  • Tumor Markers, Biological

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