Clerodane diterpenes from the bark of Casearia tremula

Simon Gibbons, Alexander I. Gray, Peter G. Waterman

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44 Citations (Scopus)

Abstract

Six novel clerodane diterpenes have been isolated from the bark of Casearia tremula. They were characterized by extensive use of Heteronuclear Multiple Bond Coherence NMR spectroscopy as rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-methoxy-2(S)-(2ξ-methylbutanoyloxy)5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene, rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(S)-(2ξ-methylbutanoyloxy)-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene, rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R)-hexanoyloxy-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene, rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy-2(S)-octanoyloxy-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy-2(S)-undecanoyloxy-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene, rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy2(S)-(2ξ-methylbutanoyloxy)-5(R),8(S),9(S),10(R)-cleroda-3,13(16),14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-6(R)-hydroxy-2(S)-(3ξ-hydroxyoctanoyloxy)-5(R),8(S),9(S), 10(R)-cleroda-3,13(16),14-triene.
Original languageEnglish
Pages (from-to)565-570
Number of pages6
JournalPhytochemistry
Volume41
Issue number2
DOIs
Publication statusPublished - 1 Feb 1996

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