Clerodane diterpenes from the leaves of Laetia procera

Simon Gibbons; Alexander I. Gray; Peter G. Waterman

doi:10.1016/0031-9422(96)00324-X

Clerodane diterpenes from the leaves of Laetia procera

Simon Gibbons, Alexander I. Gray, Peter G. Waterman

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Four novel clerodane diterpenes have been isolated from the leaves of Laetia procera. They were characterized by extensive use of HMBC spectroscopy as a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-myristoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-myristoyloxy-5(R),8(R),9(S),10(R)cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene.

Original language	English
Pages (from-to)	635-638
Number of pages	4
Journal	Phytochemistry
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/0031-9422(96)00324-X
Publication status	Published - 1 Oct 1996

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10.1016/0031-9422(96)00324-X

https://linkinghub.elsevier.com/retrieve/pii/003194229600324X

Cite this

@article{b44e485212b14d20a68a8f9e3767a498,

title = "Clerodane diterpenes from the leaves of Laetia procera",

abstract = "Four novel clerodane diterpenes have been isolated from the leaves of Laetia procera. They were characterized by extensive use of HMBC spectroscopy as a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-myristoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-myristoyloxy-5(R),8(R),9(S),10(R)cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene.",

author = "Simon Gibbons and Gray, {Alexander I.} and Waterman, {Peter G.}",

year = "1996",

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doi = "10.1016/0031-9422(96)00324-X",

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T1 - Clerodane diterpenes from the leaves of Laetia procera

AU - Gibbons, Simon

AU - Gray, Alexander I.

AU - Waterman, Peter G.

PY - 1996/10/1

Y1 - 1996/10/1

N2 - Four novel clerodane diterpenes have been isolated from the leaves of Laetia procera. They were characterized by extensive use of HMBC spectroscopy as a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-myristoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-myristoyloxy-5(R),8(R),9(S),10(R)cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene.

AB - Four novel clerodane diterpenes have been isolated from the leaves of Laetia procera. They were characterized by extensive use of HMBC spectroscopy as a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-myristoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),7(S),16-trihydroxy-6(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene and a mixture of rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-myristoyloxy-5(R),8(R),9(S),10(R)cleroda-3,12,14-triene and rel-18(S),19(R)-diacetoxy-18,19-epoxy-2(R),6(S),16-trihydroxy-7(S)-palmitoyloxy-5(R),8(R),9(S),10(R)-cleroda-3,12,14-triene.

U2 - 10.1016/0031-9422(96)00324-X

DO - 10.1016/0031-9422(96)00324-X

M3 - Article

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JF - Phytochemistry

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