As cool climate viticulture rapidly expands, the England and Wales wine sector is winning international acclaim, particularly for its sparkling wines, and is attracting significant investment. Supported by warming climate trends during the growing season, wine producers are establishing new vineyards planted predominantly with Pinot Noir and Chardonnay. Grape-friendly weather conditions in 2018 led to a record harvest and may be a sign of good things to come. Long term (100-years) Growing Season Average Temperatures (GSTs) in south-east and south-central England have noticeably increased with 6 of the top 10 warmest growing seasons (April–October), over the last 100 years, occurring since 2005. However, weather and growing season conditions fluctuate markedly from year to year, meaning that yields and grape quality continue to vary significantly. Weather extremes are anticipated to become more frequent under future climate change, further threatening the stability of production. Current uncertainty over future climatic conditions during the growing season and their potential effects on viticulture in the UK exposes both existing producers and potential investors to unquantified risks and opportunities. The CREWS-UK climate resilience research project is generating actionable information on how climate change may affect the wine production sector, to support better decision-making and investment.