Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease

J O Lindsay; K Whelan; A J Stagg; P Gobin; H O Al-Hassi; N Rayment; M A Kamm; S C Knight; A Forbes

doi:10.1136/gut.2005.074971

Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease

J O Lindsay, K Whelan, A J Stagg, P Gobin, H O Al-Hassi, N Rayment, M A Kamm, S C Knight, A Forbes

Research output: Contribution to journal › Article › peer-review

376 Citations (Scopus)

Abstract

The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease.

Original language	English
Pages (from-to)	348-355
Number of pages	8
Journal	Gut
Volume	55
Issue number	3
DOIs	https://doi.org/10.1136/gut.2005.074971
Publication status	Published - Mar 2006

Keywords

Adult
Bifidobacterium
Crohn Disease
Dendritic Cells
Feces
Female
Humans
Immunity, Mucosal
Intestinal Mucosa
Male
Middle Aged
Oligosaccharides
Patient Compliance
Severity of Illness Index
Toll-Like Receptors

Access to Document

10.1136/gut.2005.074971

Cite this

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title = "Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease",

abstract = "The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease.",

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author = "Lindsay, {J O} and K Whelan and Stagg, {A J} and P Gobin and Al-Hassi, {H O} and N Rayment and Kamm, {M A} and Knight, {S C} and A Forbes",

year = "2006",

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T1 - Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease

AU - Lindsay, J O

AU - Whelan, K

AU - Stagg, A J

AU - Gobin, P

AU - Al-Hassi, H O

AU - Rayment, N

AU - Kamm, M A

AU - Knight, S C

AU - Forbes, A

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AB - The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease.

KW - Adult

KW - Bifidobacterium

KW - Crohn Disease

KW - Dendritic Cells

KW - Feces

KW - Female

KW - Humans

KW - Immunity, Mucosal

KW - Intestinal Mucosa

KW - Male

KW - Middle Aged

KW - Oligosaccharides

KW - Patient Compliance

KW - Severity of Illness Index

KW - Toll-Like Receptors

U2 - 10.1136/gut.2005.074971

DO - 10.1136/gut.2005.074971

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JO - Gut

JF - Gut

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