Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease

J O Lindsay, K Whelan, A J Stagg, P Gobin, H O Al-Hassi, N Rayment, M A Kamm, S C Knight, A Forbes

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289 Citations (Scopus)

Abstract

The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease.
Original languageEnglish
Pages (from-to)348-355
Number of pages8
JournalGut
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Adult
  • Bifidobacterium
  • Crohn Disease
  • Dendritic Cells
  • Feces
  • Female
  • Humans
  • Immunity, Mucosal
  • Intestinal Mucosa
  • Male
  • Middle Aged
  • Oligosaccharides
  • Patient Compliance
  • Severity of Illness Index
  • Toll-Like Receptors

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