TY - JOUR
T1 - Cloning and mapping of members of the MYM family
AU - Smedley, Damian
AU - Hamoudi, Rifat
AU - Lu, Yong Jie
AU - Cooper, Colin
AU - Shipley, Janet
N1 - Funding Information:
This work included support from the Medical Research Council and Kay Kendall Leukaemia Fund.
PY - 1999/9/1
Y1 - 1999/9/1
N2 - Tandem repeats of a novel, putative, zinc-binding motif (MYM) have been described within the products of two, highly homologous genes: ZNF198/RAMP/FIM and ZNF261/DXS6673E. ZNF198, mapping to 13q11-q12, was recently shown to fuse to the fibroblast growth factor receptor 1 gene in the t(8;13)(p11;q11-q12) rearrangement associated with a stem cell leukemia/lymphoma syndrome. ZNF261 at Xq13.1 is disrupted by a t(X;13)(q13.1;q32) rearrangement in a mentally retarded patient and is a candidate gene for nonspecific X-linked mental retardation. Here we have cloned another member of this family, designated ZNF258, and mapped it to chromosome band 14q12. In addition, ZNF262/KIAA0425 was identified as a further member of the family and mapped to 1p32-p34. The predicted protein products of ZNF258 and ZNF262 maintain the repeats of the MYM motif. Isolation of these new members will facilitate the functional characterization of the MYM family and motif.
AB - Tandem repeats of a novel, putative, zinc-binding motif (MYM) have been described within the products of two, highly homologous genes: ZNF198/RAMP/FIM and ZNF261/DXS6673E. ZNF198, mapping to 13q11-q12, was recently shown to fuse to the fibroblast growth factor receptor 1 gene in the t(8;13)(p11;q11-q12) rearrangement associated with a stem cell leukemia/lymphoma syndrome. ZNF261 at Xq13.1 is disrupted by a t(X;13)(q13.1;q32) rearrangement in a mentally retarded patient and is a candidate gene for nonspecific X-linked mental retardation. Here we have cloned another member of this family, designated ZNF258, and mapped it to chromosome band 14q12. In addition, ZNF262/KIAA0425 was identified as a further member of the family and mapped to 1p32-p34. The predicted protein products of ZNF258 and ZNF262 maintain the repeats of the MYM motif. Isolation of these new members will facilitate the functional characterization of the MYM family and motif.
UR - http://www.scopus.com/inward/record.url?scp=0033200037&partnerID=8YFLogxK
U2 - 10.1006/geno.1999.5918
DO - 10.1006/geno.1999.5918
M3 - Article
C2 - 10486218
AN - SCOPUS:0033200037
VL - 60
SP - 244
EP - 247
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -