Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

Deepak L Bhatt; Keith A A Fox; Werner Hacke; Peter B Berger; Henry R Black; William E Boden; Patrice Cacoub; Eric A Cohen; Mark A Creager; J Donald Easton; Marcus D Flather; Steven M Haffner; Christian W Hamm; Graeme J Hankey; S Claiborne Johnston; Koon-Hou Mak; Jean-Louis Mas; Gilles Montalescot; Thomas A Pearson; P Gabriel Steg; Steven R Steinhubl; Michael A Weber; Danielle M Brennan; Liz Fabry-Ribaudo; Joan Booth; Eric J Topol; CHARISMA Investigators

doi:10.1056/NEJMoa060989

Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

Deepak L Bhatt, Keith A A Fox, Werner Hacke, Peter B Berger, Henry R Black, William E Boden, Patrice Cacoub, Eric A Cohen, Mark A Creager, J Donald Easton, Marcus D Flather, Steven M Haffner, Christian W Hamm, Graeme J Hankey, S Claiborne Johnston, Koon-Hou Mak, Jean-Louis Mas, Gilles Montalescot, Thomas A Pearson, P Gabriel StegSteven R Steinhubl, Michael A Weber, Danielle M Brennan, Liz Fabry-Ribaudo, Joan Booth, Eric J Topol, CHARISMA Investigators

Research output: Contribution to journal › Article › peer-review

2554 Citations (SciVal)

Abstract

Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events.

Original language	English
Pages (from-to)	1706-17
Number of pages	12
Journal	New England Journal of Medicine
Volume	354
Issue number	16
DOIs	https://doi.org/10.1056/NEJMoa060989
Publication status	Published - 20 Apr 2006

Keywords

Adult
Aged
Aged, 80 and over
Aspirin
Cardiovascular Diseases
Data Interpretation, Statistical
Double-Blind Method
Drug Therapy, Combination
Female
Hemorrhage
Humans
Male
Middle Aged
Myocardial Infarction
Platelet Aggregation Inhibitors
Proportional Hazards Models
Prospective Studies
Risk Factors
Stroke
Thrombosis
Ticlopidine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1056/NEJMoa060989

Cite this

Bhatt, D. L., Fox, K. A. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Flather, M. D., Haffner, S. M., Hamm, C. W., Hankey, G. J., Johnston, S. C., Mak, K-H., Mas, J-L., Montalescot, G., Pearson, T. A., ... CHARISMA Investigators (2006). Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. New England Journal of Medicine, 354(16), 1706-17. https://doi.org/10.1056/NEJMoa060989

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title = "Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events",

abstract = "Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events.",

keywords = "Adult, Aged, Aged, 80 and over, Aspirin, Cardiovascular Diseases, Data Interpretation, Statistical, Double-Blind Method, Drug Therapy, Combination, Female, Hemorrhage, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Proportional Hazards Models, Prospective Studies, Risk Factors, Stroke, Thrombosis, Ticlopidine",

author = "Bhatt, {Deepak L} and Fox, {Keith A A} and Werner Hacke and Berger, {Peter B} and Black, {Henry R} and Boden, {William E} and Patrice Cacoub and Cohen, {Eric A} and Creager, {Mark A} and Easton, {J Donald} and Flather, {Marcus D} and Haffner, {Steven M} and Hamm, {Christian W} and Hankey, {Graeme J} and Johnston, {S Claiborne} and Koon-Hou Mak and Jean-Louis Mas and Gilles Montalescot and Pearson, {Thomas A} and Steg, {P Gabriel} and Steinhubl, {Steven R} and Weber, {Michael A} and Brennan, {Danielle M} and Liz Fabry-Ribaudo and Joan Booth and Topol, {Eric J} and {CHARISMA Investigators}",

year = "2006",

month = apr,

day = "20",

doi = "10.1056/NEJMoa060989",

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Bhatt, DL, Fox, KAA, Hacke, W, Berger, PB, Black, HR, Boden, WE, Cacoub, P, Cohen, EA, Creager, MA, Easton, JD, Flather, MD, Haffner, SM, Hamm, CW, Hankey, GJ, Johnston, SC, Mak, K-H, Mas, J-L, Montalescot, G, Pearson, TA, Steg, PG, Steinhubl, SR, Weber, MA, Brennan, DM, Fabry-Ribaudo, L, Booth, J, Topol, EJ & CHARISMA Investigators 2006, 'Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events', New England Journal of Medicine, vol. 354, no. 16, pp. 1706-17. https://doi.org/10.1056/NEJMoa060989

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AU - Bhatt, Deepak L

AU - Fox, Keith A A

AU - Hacke, Werner

AU - Berger, Peter B

AU - Black, Henry R

AU - Boden, William E

AU - Cacoub, Patrice

AU - Cohen, Eric A

AU - Creager, Mark A

AU - Easton, J Donald

AU - Flather, Marcus D

AU - Haffner, Steven M

AU - Hamm, Christian W

AU - Hankey, Graeme J

AU - Johnston, S Claiborne

AU - Mak, Koon-Hou

AU - Mas, Jean-Louis

AU - Montalescot, Gilles

AU - Pearson, Thomas A

AU - Steg, P Gabriel

AU - Steinhubl, Steven R

AU - Weber, Michael A

AU - Brennan, Danielle M

AU - Fabry-Ribaudo, Liz

AU - Booth, Joan

AU - Topol, Eric J

AU - CHARISMA Investigators

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KW - Cardiovascular Diseases

KW - Data Interpretation, Statistical

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Female

KW - Hemorrhage

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Platelet Aggregation Inhibitors

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Factors

KW - Stroke

KW - Thrombosis

KW - Ticlopidine

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