Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

Deepak L Bhatt, Keith A A Fox, Werner Hacke, Peter B Berger, Henry R Black, William E Boden, Patrice Cacoub, Eric A Cohen, Mark A Creager, J Donald Easton, Marcus D Flather, Steven M Haffner, Christian W Hamm, Graeme J Hankey, S Claiborne Johnston, Koon-Hou Mak, Jean-Louis Mas, Gilles Montalescot, Thomas A Pearson, P Gabriel StegSteven R Steinhubl, Michael A Weber, Danielle M Brennan, Liz Fabry-Ribaudo, Joan Booth, Eric J Topol, CHARISMA Investigators

Research output: Contribution to journalArticlepeer-review

2336 Citations (Scopus)

Abstract

Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events.
Original languageEnglish
Pages (from-to)1706-17
Number of pages12
JournalNew England Journal of Medicine
Volume354
Issue number16
DOIs
Publication statusPublished - 20 Apr 2006

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Aspirin
  • Cardiovascular Diseases
  • Data Interpretation, Statistical
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Hemorrhage
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Platelet Aggregation Inhibitors
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Stroke
  • Thrombosis
  • Ticlopidine

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