COI1: An Arabidopsis gene required for jasmonate-regulated defense and fertility

Dao-Xin Xie, Bart F. Feys, Sarah James, Manuela Nieto-Rostro, John G. Turner

Research output: Contribution to journalArticlepeer-review

1358 Citations (Scopus)


The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wound healing, and pollen fertility. The wild-type allele, COI1, was mapped to a 90-kilobase genomic fragment and located by complementation of coi1-1 mutants. The predicted amino acid sequence of the COI1 protein contains 16 leucine-rich repeats and an F-box motif. It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination.
Original languageEnglish
Pages (from-to)1091-1094
Number of pages4
Issue number5366
Publication statusPublished - 15 May 1998

Cite this