Collective protein dynamics in relation to function

Herman J. C. Berendsen, Steven Hayward

Research output: Contribution to journalArticlepeer-review

364 Citations (Scopus)


Several techniques for the analysis of the internal motions of proteins are available — separating large collective motions from small, presumably uninteresting motions. Such descriptions are helpful in the characterization of internal motions and provide insight into the energy landscape of proteins. The real challenge, however, is to relate large collective motions to functional properties, such as binding and regulation, or to folding. These issues have been recently addressed in several papers.
Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalCurrent Opinion in Structural Biology
Issue number2
Publication statusPublished - Apr 2000

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