Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro

Lawrence N Barrera, Ian T Johnson, Yongping Bao, Aedin Cassidy, Nigel J Belshaw

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


It is relatively unknown how different dietary components, in partnership, regulate gene expression linked to colon pathology. It has been suggested that the combination of various bioactive components present in a plant-based diet is crucial for their potential anticancer activities. This study employed a combinatorial chemopreventive strategy to investigate the impact of selenium and/or isothiocyanates on DNA methylation processes in colorectal carcinoma cell lines.
Original languageEnglish
Pages (from-to)1327-41
Number of pages15
JournalEuropean Journal of Nutrition
Issue number4
Publication statusPublished - Jun 2013

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