Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro

Lawrence N. Barrera; Ian T. Johnson; Yongping Bao; Aedin Cassidy; Nigel J. Belshaw

doi:10.1007/s00394-012-0442-1

Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro

Lawrence N. Barrera, Ian T. Johnson, Yongping Bao, Aedin Cassidy, Nigel J. Belshaw

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

It is relatively unknown how different dietary components, in partnership, regulate gene expression linked to colon pathology. It has been suggested that the combination of various bioactive components present in a plant-based diet is crucial for their potential anticancer activities. This study employed a combinatorial chemopreventive strategy to investigate the impact of selenium and/or isothiocyanates on DNA methylation processes in colorectal carcinoma cell lines.

Original language	English
Pages (from-to)	1327-1341
Number of pages	15
Journal	European Journal of Nutrition
Volume	52
Issue number	4
DOIs	https://doi.org/10.1007/s00394-012-0442-1
Publication status	Published - Jun 2013

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10.1007/s00394-012-0442-1

Cite this

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title = "Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro",

abstract = "It is relatively unknown how different dietary components, in partnership, regulate gene expression linked to colon pathology. It has been suggested that the combination of various bioactive components present in a plant-based diet is crucial for their potential anticancer activities. This study employed a combinatorial chemopreventive strategy to investigate the impact of selenium and/or isothiocyanates on DNA methylation processes in colorectal carcinoma cell lines.",

author = "Barrera, {Lawrence N.} and Johnson, {Ian T.} and Yongping Bao and Aedin Cassidy and Belshaw, {Nigel J.}",

note = "Funding information: This work was supported by a joint PhD Studentship by the Norwich Medical School, University of East Anglia and by the BBSRC Institute of Food Research, Norwich, UK, and in part by the Overseas Research Students Awards Scheme (ORSAS), United Kingdom",

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AU - Barrera, Lawrence N.

AU - Johnson, Ian T.

AU - Bao, Yongping

AU - Cassidy, Aedin

AU - Belshaw, Nigel J.

N1 - Funding information: This work was supported by a joint PhD Studentship by the Norwich Medical School, University of East Anglia and by the BBSRC Institute of Food Research, Norwich, UK, and in part by the Overseas Research Students Awards Scheme (ORSAS), United Kingdom

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AB - It is relatively unknown how different dietary components, in partnership, regulate gene expression linked to colon pathology. It has been suggested that the combination of various bioactive components present in a plant-based diet is crucial for their potential anticancer activities. This study employed a combinatorial chemopreventive strategy to investigate the impact of selenium and/or isothiocyanates on DNA methylation processes in colorectal carcinoma cell lines.

U2 - 10.1007/s00394-012-0442-1

DO - 10.1007/s00394-012-0442-1

M3 - Article

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