Combining two-directional synthesis and tandem reactions. Part 4: A concise approach to the spirocyclic core of halichlorine and the pinnaic acids

Louise G. Arini, Peter Szeto, David L. Hughes, Robert A. Stockman

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39 Citations (Scopus)


A synthesis of the spirocyclic core structure of halichlorine, an inhibitor of the induced expression of VCAM-1 and the pinnaic acids, inhibitors of PLA2, is presented. A two-directional strategy is employed, in conjunction with a tandem oxime formation/Michael addition/cycloaddition to form the key azaspirocyclic skeleton in a very direct manner.
Original languageEnglish
Pages (from-to)8371-8374
Number of pages4
JournalTetrahedron Letters
Issue number45
Publication statusPublished - 1 Nov 2004

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