Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Maryam Rakhshandehroo; Guido Hooiveld; Michael Müller; Sander Kersten

doi:10.1371/journal.pone.0006796

Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Maryam Rakhshandehroo, Guido Hooiveld, Michael Müller, Sander Kersten

Research output: Contribution to journal › Article › peer-review

250 Citations (Scopus)

Abstract

Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver. Here we set out to compare the function of PPARalpha in mouse and human hepatocytes via analysis of target gene regulation.

Original language	English
Article number	e6796
Journal	PLoS One
Volume	4
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0006796
Publication status	Published - 27 Aug 2009

Keywords

Animals
Gene Expression Regulation
Hepatocytes
Humans
Lipid Metabolism
Mice
PPAR alpha
Peroxisome Proliferators
Pyrimidines
Species Specificity

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10.1371/journal.pone.0006796Licence: CC BY

Cite this

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KW - Lipid Metabolism

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KW - Pyrimidines

KW - Species Specificity

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