Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

Maryam Rakhshandehroo, Guido Hooiveld, Michael Müller, Sander Kersten

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205 Citations (Scopus)

Abstract

Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver. Here we set out to compare the function of PPARalpha in mouse and human hepatocytes via analysis of target gene regulation.
Original languageEnglish
Article numbere6796
JournalPLoS One
Volume4
Issue number8
DOIs
Publication statusPublished - 27 Aug 2009

Keywords

  • Animals
  • Gene Expression Regulation
  • Hepatocytes
  • Humans
  • Lipid Metabolism
  • Mice
  • PPAR alpha
  • Peroxisome Proliferators
  • Pyrimidines
  • Species Specificity

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