Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae

Neil Woodford; Anne T. Eastaway; Michael Ford; Alistair Leanord; Chloe Keane; Reinhard M. Quayle; Jane A. Steer; Jiancheng Zhang; Daivd M. Livermore

doi:10.1128/JCM.00341-10

Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae

Neil Woodford, Anne T. Eastaway, Michael Ford, Alistair Leanord, Chloe Keane, Reinhard M. Quayle, Jane A. Steer, Jiancheng Zhang, Daivd M. Livermore

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

We assessed the ability of three commercial systems to infer carbapenem resistance mechanisms in 39 carbapenemase-producing and 16 other carbapenem-resistant Enterobacteriaceae. The sensitivity/specificity values for “flagging” a likely carbapenemase were 100%/0% (BD Phoenix), 82 to 85%/6 to 19% (MicroScan), and 74%/38% (Vitek 2), respectively. OXA-48 producers were poorly detected, but all systems reliably detected isolates with KPC and most with metallo-carbapenemases.

Original language	English
Pages (from-to)	2999-3002
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	48
Issue number	8
DOIs	https://doi.org/10.1128/JCM.00341-10
Publication status	Published - Aug 2010

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10.1128/JCM.00341-10

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Woodford, N., Eastaway, A. T., Ford, M., Leanord, A., Keane, C., Quayle, R. M., Steer, J. A., Zhang, J., & Livermore, D. M. (2010). Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae. Journal of Clinical Microbiology, 48(8), 2999-3002. https://doi.org/10.1128/JCM.00341-10

Woodford, Neil ; Eastaway, Anne T. ; Ford, Michael ; Leanord, Alistair ; Keane, Chloe ; Quayle, Reinhard M. ; Steer, Jane A. ; Zhang, Jiancheng ; Livermore, Daivd M. / Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae. In: Journal of Clinical Microbiology. 2010 ; Vol. 48, No. 8. pp. 2999-3002.

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title = "Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae",

abstract = "We assessed the ability of three commercial systems to infer carbapenem resistance mechanisms in 39 carbapenemase-producing and 16 other carbapenem-resistant Enterobacteriaceae. The sensitivity/specificity values for “flagging” a likely carbapenemase were 100%/0% (BD Phoenix), 82 to 85%/6 to 19% (MicroScan), and 74%/38% (Vitek 2), respectively. OXA-48 producers were poorly detected, but all systems reliably detected isolates with KPC and most with metallo-carbapenemases.",

author = "Neil Woodford and Eastaway, {Anne T.} and Michael Ford and Alistair Leanord and Chloe Keane and Quayle, {Reinhard M.} and Steer, {Jane A.} and Jiancheng Zhang and Livermore, {Daivd M.}",

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Woodford, N, Eastaway, AT, Ford, M, Leanord, A, Keane, C, Quayle, RM, Steer, JA, Zhang, J & Livermore, DM 2010, 'Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae', Journal of Clinical Microbiology, vol. 48, no. 8, pp. 2999-3002. https://doi.org/10.1128/JCM.00341-10

Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae. / Woodford, Neil; Eastaway, Anne T.; Ford, Michael; Leanord, Alistair; Keane, Chloe; Quayle, Reinhard M.; Steer, Jane A.; Zhang, Jiancheng; Livermore, Daivd M.

In: Journal of Clinical Microbiology, Vol. 48, No. 8, 08.2010, p. 2999-3002.

Research output: Contribution to journal › Article › peer-review

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