Comparison of BD Phoenix, Vitek 2, and MicroScan Automated Systems for Detection and Inference of Mechanisms Responsible for Carbapenem Resistance in Enterobacteriaceae

Neil Woodford, Anne T. Eastaway, Michael Ford, Alistair Leanord, Chloe Keane, Reinhard M. Quayle, Jane A. Steer, Jiancheng Zhang, Daivd M. Livermore

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Abstract

We assessed the ability of three commercial systems to infer carbapenem resistance mechanisms in 39 carbapenemase-producing and 16 other carbapenem-resistant Enterobacteriaceae. The sensitivity/specificity values for “flagging” a likely carbapenemase were 100%/0% (BD Phoenix), 82 to 85%/6 to 19% (MicroScan), and 74%/38% (Vitek 2), respectively. OXA-48 producers were poorly detected, but all systems reliably detected isolates with KPC and most with metallo-carbapenemases.
Original languageEnglish
Pages (from-to)2999-3002
Number of pages4
JournalJournal of Clinical Microbiology
Volume48
Issue number8
DOIs
Publication statusPublished - Aug 2010

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