Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade

Meng Law; Stanley Yang; James S. Babb; Edmond A. Knopp; John G. Golfinos; David Zagzag; Glyn Johnson

Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade

Meng Law, Stanley Yang, James S. Babb, Edmond A. Knopp, John G. Golfinos, David Zagzag, Glyn Johnson

Research output: Contribution to journal › Article › peer-review

443 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) permit in vivo assessment of glioma microvasculature. We assessed the associations between rCBV and K(trans) derived from dynamic, susceptibility-weighted, contrast-enhanced (DSC) MR imaging and tumor grade and between rCBV and K(trans). METHODS: Seventy-three patients with primary gliomas underwent conventional and DSC MR imaging. rCBVs were obtained from regions of maximal abnormality for each lesion on rCBV color maps. K(trans) was derived from a pharmacokinetic modeling algorithm. Histopathologic grade was compared with rCBV and K(trans) (Tukey honestly significant difference). Spearman and Pearson correlation factors were determined between rCBV, K(trans), and tumor grade. The diagnostic utility of rCBV and K(trans) in discriminating grade II or III tumors from grade I tumors was assessed by logistic regression. RESULTS: rCBV was significantly different for all three grades (P

Original language	English
Pages (from-to)	746-755
Number of pages	9
Journal	American Journal of Neuroradiology
Volume	25
Issue number	5
Publication status	Published - 2004

Keywords

Adolescent Adult Aged Aged
80 and over
Blood Volume Brain Neoplasms
blood supply
pathology
physiopathology
Capillary Permeability
Cerebrovascular Circulation Child
Preschool Contrast Media Female Glioma
physiopathology Humans
Magnetic Resonance Imaging
methods Male Middle Aged Retrospective Studies

Access to Document

http://www.ajnr.org/content/25/5/746.full

Cite this

@article{7e4fb0d297d8444ab969a8a64d51d4bd,

title = "Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade",

abstract = "BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) permit in vivo assessment of glioma microvasculature. We assessed the associations between rCBV and K(trans) derived from dynamic, susceptibility-weighted, contrast-enhanced (DSC) MR imaging and tumor grade and between rCBV and K(trans). METHODS: Seventy-three patients with primary gliomas underwent conventional and DSC MR imaging. rCBVs were obtained from regions of maximal abnormality for each lesion on rCBV color maps. K(trans) was derived from a pharmacokinetic modeling algorithm. Histopathologic grade was compared with rCBV and K(trans) (Tukey honestly significant difference). Spearman and Pearson correlation factors were determined between rCBV, K(trans), and tumor grade. The diagnostic utility of rCBV and K(trans) in discriminating grade II or III tumors from grade I tumors was assessed by logistic regression. RESULTS: rCBV was significantly different for all three grades (P ",

keywords = "Adolescent Adult Aged Aged, 80 and over , Blood Volume Brain Neoplasms, blood supply, pathology, physiopathology, Capillary Permeability , Cerebrovascular Circulation Child, Preschool Contrast Media Female Glioma, physiopathology Humans , Magnetic Resonance Imaging, methods Male Middle Aged Retrospective Studies",

author = "Meng Law and Stanley Yang and Babb, {James S.} and Knopp, {Edmond A.} and Golfinos, {John G.} and David Zagzag and Glyn Johnson",

year = "2004",

language = "English",

volume = "25",

pages = "746--755",

journal = "American Journal of Neuroradiology",

issn = "0195-6108",

publisher = "American Society of Neuroradiology",

number = "5",

}

Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. / Law, Meng; Yang, Stanley; Babb, James S.; Knopp, Edmond A.; Golfinos, John G.; Zagzag, David; Johnson, Glyn.

In: American Journal of Neuroradiology, Vol. 25, No. 5, 2004, p. 746-755.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade

AU - Law, Meng

AU - Yang, Stanley

AU - Babb, James S.

AU - Knopp, Edmond A.

AU - Golfinos, John G.

AU - Zagzag, David

AU - Johnson, Glyn

PY - 2004

Y1 - 2004

N2 - BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) permit in vivo assessment of glioma microvasculature. We assessed the associations between rCBV and K(trans) derived from dynamic, susceptibility-weighted, contrast-enhanced (DSC) MR imaging and tumor grade and between rCBV and K(trans). METHODS: Seventy-three patients with primary gliomas underwent conventional and DSC MR imaging. rCBVs were obtained from regions of maximal abnormality for each lesion on rCBV color maps. K(trans) was derived from a pharmacokinetic modeling algorithm. Histopathologic grade was compared with rCBV and K(trans) (Tukey honestly significant difference). Spearman and Pearson correlation factors were determined between rCBV, K(trans), and tumor grade. The diagnostic utility of rCBV and K(trans) in discriminating grade II or III tumors from grade I tumors was assessed by logistic regression. RESULTS: rCBV was significantly different for all three grades (P

AB - BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) permit in vivo assessment of glioma microvasculature. We assessed the associations between rCBV and K(trans) derived from dynamic, susceptibility-weighted, contrast-enhanced (DSC) MR imaging and tumor grade and between rCBV and K(trans). METHODS: Seventy-three patients with primary gliomas underwent conventional and DSC MR imaging. rCBVs were obtained from regions of maximal abnormality for each lesion on rCBV color maps. K(trans) was derived from a pharmacokinetic modeling algorithm. Histopathologic grade was compared with rCBV and K(trans) (Tukey honestly significant difference). Spearman and Pearson correlation factors were determined between rCBV, K(trans), and tumor grade. The diagnostic utility of rCBV and K(trans) in discriminating grade II or III tumors from grade I tumors was assessed by logistic regression. RESULTS: rCBV was significantly different for all three grades (P

KW - Adolescent Adult Aged Aged

KW - 80 and over

KW - Blood Volume Brain Neoplasms

KW - blood supply

KW - pathology

KW - physiopathology

KW - Capillary Permeability

KW - Cerebrovascular Circulation Child

KW - Preschool Contrast Media Female Glioma

KW - physiopathology Humans

KW - Magnetic Resonance Imaging

KW - methods Male Middle Aged Retrospective Studies

M3 - Article

VL - 25

SP - 746

EP - 755

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 5

ER -