Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade

Meng Law, Stanley Yang, James S. Babb, Edmond A. Knopp, John G. Golfinos, David Zagzag, Glyn Johnson

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BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) permit in vivo assessment of glioma microvasculature. We assessed the associations between rCBV and K(trans) derived from dynamic, susceptibility-weighted, contrast-enhanced (DSC) MR imaging and tumor grade and between rCBV and K(trans). METHODS: Seventy-three patients with primary gliomas underwent conventional and DSC MR imaging. rCBVs were obtained from regions of maximal abnormality for each lesion on rCBV color maps. K(trans) was derived from a pharmacokinetic modeling algorithm. Histopathologic grade was compared with rCBV and K(trans) (Tukey honestly significant difference). Spearman and Pearson correlation factors were determined between rCBV, K(trans), and tumor grade. The diagnostic utility of rCBV and K(trans) in discriminating grade II or III tumors from grade I tumors was assessed by logistic regression. RESULTS: rCBV was significantly different for all three grades (P
Original languageEnglish
Pages (from-to)746-755
Number of pages9
JournalAmerican Journal of Neuroradiology
Issue number5
Publication statusPublished - 2004


  • Adolescent Adult Aged Aged
  • 80 and over
  • Blood Volume Brain Neoplasms
  • blood supply
  • pathology
  • physiopathology
  • Capillary Permeability
  • Cerebrovascular Circulation Child
  • Preschool Contrast Media Female Glioma
  • physiopathology Humans
  • Magnetic Resonance Imaging
  • methods Male Middle Aged Retrospective Studies

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