Compassionate use of cefiderocol as adjunctive treatment of native aortic valve endocarditis due to XDR-Pseudomonas aeruginosa

Jonathan D Edgeworth; Domenico Merante; Sanjay Patel; Christopher Young; Paul Jones; Seema Vithlani; Duncan Wyncoll; Peter Roberts; Andrew Jones; Tsutae Den Nagata; Mari Ariyasu; David M Livermore; Richard Beale

doi:10.1093/cid/ciy963

Compassionate use of cefiderocol as adjunctive treatment of native aortic valve endocarditis due to XDR-Pseudomonas aeruginosa

Jonathan D Edgeworth, Domenico Merante, Sanjay Patel, Christopher Young, Paul Jones, Seema Vithlani, Duncan Wyncoll, Peter Roberts, Andrew Jones, Tsutae Den Nagata, Mari Ariyasu, David M Livermore, Richard Beale

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Abstract

Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

Original language	English
Pages (from-to)	1932–1934
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	68
Issue number	11
Early online date	12 Nov 2018
DOIs	https://doi.org/10.1093/cid/ciy963
Publication status	Published - 1 Jun 2019

Keywords

Cefiderocol
Pseudomonas aeruginosa
drug resistance
endocarditis
microbial

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Accepted author manuscript, 483 KBLicence: CC BY
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Edgeworth, J. D., Merante, D., Patel, S., Young, C., Jones, P., Vithlani, S., Wyncoll, D., Roberts, P., Jones, A., Nagata, T. D., Ariyasu, M., Livermore, D. M., & Beale, R. (2019). Compassionate use of cefiderocol as adjunctive treatment of native aortic valve endocarditis due to XDR-Pseudomonas aeruginosa. Clinical Infectious Diseases, 68(11), 1932–1934. https://doi.org/10.1093/cid/ciy963

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abstract = "Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.",

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Edgeworth, JD, Merante, D, Patel, S, Young, C, Jones, P, Vithlani, S, Wyncoll, D, Roberts, P, Jones, A, Nagata, TD, Ariyasu, M, Livermore, DM & Beale, R 2019, 'Compassionate use of cefiderocol as adjunctive treatment of native aortic valve endocarditis due to XDR-Pseudomonas aeruginosa', Clinical Infectious Diseases, vol. 68, no. 11, pp. 1932–1934. https://doi.org/10.1093/cid/ciy963

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AU - Edgeworth, Jonathan D

AU - Merante, Domenico

AU - Patel, Sanjay

AU - Young, Christopher

AU - Jones, Paul

AU - Vithlani, Seema

AU - Wyncoll, Duncan

AU - Roberts, Peter

AU - Jones, Andrew

AU - Nagata, Tsutae Den

AU - Ariyasu, Mari

AU - Livermore, David M

AU - Beale, Richard

PY - 2019/6/1

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AB - Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated native aortic valve endocarditis due to an extended-spectrum beta-lactamase-positive Pseudomonas aeruginosa susceptible in vitro only to colistin, following failure of conventional therapeutic options.

KW - Cefiderocol

KW - Pseudomonas aeruginosa

KW - drug resistance

KW - endocarditis

KW - microbial

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JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 11

ER -

Compassionate use of cefiderocol as adjunctive treatment of native aortic valve endocarditis due to XDR-Pseudomonas aeruginosa

Abstract

Keywords

UN SDGs

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