Complete genome sequence of Streptomyces formicae KY5, the formicamycin producer

Neil A. Holmes, Rebecca Devine, Zhiwei Qin, Ryan F. Seipke, Barrie Wilkinson, Matthew I. Hutchings

Research output: Contribution to journalArticlepeer-review

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Abstract

Here we report the complete genome of the new species Streptomyces formicae KY5 isolated from Tetraponera fungus growing ants. S. formicae was sequenced using the PacBio and 454 platforms to generate a single linear chromosome with terminal inverted repeats. Illumina MiSeq sequencing was used to correct base changes resulting from the high error rate associated with PacBio. The genome is 9.6 Mbps, has a GC content of 71.38% and contains 8162 protein coding sequences. Predictive analysis shows this strain encodes at least 45 gene clusters for the biosynthesis of secondary metabolites, including a type 2 polyketide synthase encoding cluster for the antibacterial formicamycins. Streptomyces formicae KY5 is a new, taxonomically distinct Streptomyces species and this complete genome sequence provides an important marker in the genus of Streptomyces.
Original languageEnglish
Pages (from-to)116–118
Number of pages3
JournalJournal of Biotechnology
Volume265
Early online date27 Nov 2017
DOIs
Publication statusPublished - 10 Jan 2018

Keywords

  • Streptomyces formicae KY5
  • Tetraponera penzigi
  • Genome sequence
  • Antibiotics
  • Secondary metabolites

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