Complex desorption of mucin from silica

James McColl, Gleb E. Yakubov, Jeremy J. Ramsden

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Complex solutes may adsorb from solution onto solid surfaces in a concentration-dependent manner. In other words, the adsorption behavior is qualitatively different in different bulk concentration regimes. Here we show that the large glycoprotein mucin not only adsorbs in distinctively different ways according to the bulk concentration but also, strikingly, that the law of desorption, established with the help of high-resolution molecular microscopy, depends on the bulk concentration during adsorption. Making use of supporting bulk rheology data delineating the entangled regime and atomic force microscopy images of the adsorbed layers corroborating the existence of a bilayer structure formed at higher bulk concentrations, a tentative molecular mechanism for the observations is proposed.
Original languageEnglish
Pages (from-to)7096–7100
Number of pages5
Issue number13
Early online date16 May 2007
Publication statusPublished - 1 Jun 2007

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