Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy

Yangziwan Weng; Shanyue Guan; Heng Lu; Xiangmin Meng; Abdessamad. Y Kaassis; Xiaoxue Ren; Xiaozhong Qu; Chenghua Sun; Zheng Xie; Shuyun Zhou

doi:10.1016/j.talanta.2018.02.093

Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy

Yangziwan Weng, Shanyue Guan, Heng Lu, Xiangmin Meng, Abdessamad. Y Kaassis, Xiaoxue Ren, Xiaozhong Qu, Chenghua Sun, Zheng Xie, Shuyun Zhou

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

7 Downloads (Pure)

Abstract

It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Talanta
Volume	184
Early online date	27 Feb 2018
DOIs	https://doi.org/10.1016/j.talanta.2018.02.093
Publication status	Published - 1 Jul 2018

Keywords

Carbon dots
Ultrathin layered double hydroxides
Triple-mode imaging Photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.talanta.2018.02.093

Accepted manuscriptAccepted author manuscript, 1.44 MBLicence: CC BY-NC-ND

http://linkinghub.elsevier.com/retrieve/pii/S0039914018302145

Cite this

@article{5e9b2b6f56fe41c6a583f7510c8f3c66,

title = "Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy",

abstract = "It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.",

keywords = "Carbon dots, Ultrathin layered double hydroxides, Triple-mode imaging Photothermal therapy",

author = "Yangziwan Weng and Shanyue Guan and Heng Lu and Xiangmin Meng and Kaassis, {Abdessamad. Y} and Xiaoxue Ren and Xiaozhong Qu and Chenghua Sun and Zheng Xie and Shuyun Zhou",

year = "2018",

month = jul,

day = "1",

doi = "10.1016/j.talanta.2018.02.093",

language = "English",

volume = "184",

pages = "50--57",

journal = "Talanta",

issn = "0039-9140",

publisher = "Elsevier",

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Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy. / Weng, Yangziwan; Guan, Shanyue; Lu, Heng; Meng, Xiangmin; Kaassis, Abdessamad. Y; Ren, Xiaoxue; Qu, Xiaozhong; Sun, Chenghua; Xie, Zheng; Zhou, Shuyun.

In: Talanta, Vol. 184, 01.07.2018, p. 50-57.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy

AU - Weng, Yangziwan

AU - Guan, Shanyue

AU - Lu, Heng

AU - Meng, Xiangmin

AU - Kaassis, Abdessamad. Y

AU - Ren, Xiaoxue

AU - Qu, Xiaozhong

AU - Sun, Chenghua

AU - Xie, Zheng

AU - Zhou, Shuyun

PY - 2018/7/1

Y1 - 2018/7/1

N2 - It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.

AB - It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.

KW - Carbon dots

KW - Ultrathin layered double hydroxides

KW - Triple-mode imaging Photothermal therapy

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