Confinement of carbon dots localizing to the ultrathin layered double hydroxides toward simultaneous triple-mode bioimaging and photothermal therapy

Yangziwan Weng, Shanyue Guan, Heng Lu, Xiangmin Meng, Abdessamad. Y Kaassis, Xiaoxue Ren, Xiaozhong Qu, Chenghua Sun, Zheng Xie, Shuyun Zhou

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37 Citations (Scopus)
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It is a great challenge to develop multifunctional nanocarriers for cancer diagnosis and therapy. Herein, versatile CDs/ICG-uLDHs nanovehicles for triple-modal fluorescence/photoacoustic/two-photon bioimaging and effective photothermal therapy were prepared via a facile self-assembly of red emission carbon dots (CDs), indocyanine green (ICG) with the ultrathin layered double hydroxides (uLDHs). Due to the J-aggregates of ICG constructed in the self-assembly process, CDs/ICG-uLDHs was able to stabilize the photothermal agent ICG and enhanced its photothermal efficiency. Furthermore, the unique confinement effect of uLDHs has extended the fluorescence lifetime of CDs in favor of bioimaging. Considering the excellent in vitro and in vivo phototherapeutics and multimodal imaging effects, this work provides a promising platform for the construction of multifunctional theranostic nanocarrier system for the cancer treatment.
Original languageEnglish
Pages (from-to)50-57
Number of pages8
Early online date27 Feb 2018
Publication statusPublished - 1 Jul 2018


  • Carbon dots
  • Ultrathin layered double hydroxides
  • Triple-mode imaging Photothermal therapy

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