Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

Yuen Li Chung; Alun Williams; Diane Ritchie; Steve C.R. Williams; K. Kumar Changani; James Hope; Jimmy D. Bell

doi:10.1097/00001756-199911260-00002

Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

Yuen Li Chung, Alun Williams, Diane Ritchie, Steve C.R. Williams, K. Kumar Changani, James Hope, Jimmy D. Bell

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data.

Original language	English
Pages (from-to)	3471-3477
Number of pages	7
Journal	NeuroReport
Volume	10
Issue number	17
DOIs	https://doi.org/10.1097/00001756-199911260-00002
Publication status	Published - 26 Nov 1999

Keywords

CJD
Hamster
Histopathology
Magnetic resonance imaging
Scrapie

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10.1097/00001756-199911260-00002

Cite this

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abstract = "MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data.",

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AU - Hope, James

AU - Bell, Jimmy D.

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AB - MAGNETIC resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data.

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Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

Abstract

Keywords

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