Confocal laser endomicroscopy in gastrointestinal diseases

Martin Goetz, Alastair Watson, Ralf Kiesslich

Research output: Contribution to journalArticlepeer-review

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Confocal laser endomicroscopy (CLE) is a novel endoscopic technique permitting in vivo microscopy (optical biopsies) of the gastrointestinal mucosa. CLE has been studied in a multitude of diseases of the upper and lower gastrointestinal tract, including Barrett's esophagus, gastric inflammation and cancer, celiac disease, colorectal adenoma and carcinoma, and inflammatory bowel diseases. CLE has recently evolved and been studied for bile duct and liver imaging. CLE has shown overall high accuracy and enabled smart, targeted biopsies rather than untargeted sampling. Furthermore, the availability of real time microscopic information during endoscopy has immediate impact on therapeutic decisions and guides endoscopic interventions. CLE is also a unique tool for observation of (patho-)physiologic events in their natural environment (functional imaging) and has been linked to molecular imaging of gastrointestinal neoplasia in vivo, thereby broadening our understanding of mucosal pathology in clinical and basic science.
Original languageEnglish
Pages (from-to)498-508
Number of pages11
JournalJournal of Biophotonics
Issue number7-8
Publication statusPublished - Aug 2011


  • Animals
  • Endoscopy, Gastrointestinal
  • Gastrointestinal Diseases
  • Humans
  • Lasers
  • Lower Gastrointestinal Tract
  • Microscopy, Confocal
  • Staining and Labeling
  • Upper Gastrointestinal Tract

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