Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo

Driffa Moussata; Martin Goetz; Annabel Gloeckner; Marcus Kerner; Barry Campbell; Arthur Hoffman; Stephan Biesterfeld; Bernard Flourie; Jean-Christophe Saurin; Peter R Galle; Markus F Neurath; Alastair J M Watson; Ralf Kiesslich

doi:10.1136/gut.2010.213264

Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo

Driffa Moussata, Martin Goetz, Annabel Gloeckner, Marcus Kerner, Barry Campbell, Arthur Hoffman, Stephan Biesterfeld, Bernard Flourie, Jean-Christophe Saurin, Peter R Galle, Markus F Neurath, Alastair J M Watson, Ralf Kiesslich

Research output: Contribution to journal › Article › peer-review

112 Citations (Scopus)

Abstract

Interaction of bacteria with the immune system within the intestinal mucosa plays a key role in the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to develop a fluorescein-aided confocal laser endomicroscopy (CLE) method to visualise intramucosal enteric bacteria in vivo and to determine the involved mucosal area in the colon and ileum in patients with ulcerative colitis (UC) and Crohn's disease (CD).

Original language	English
Pages (from-to)	26-33
Number of pages	8
Journal	Gut
Volume	60
Issue number	1
DOIs	https://doi.org/10.1136/gut.2010.213264
Publication status	Published - Jan 2011

Keywords

Animals
Colitis, Ulcerative
Colon
Colonoscopy
Crohn Disease
Enterobacteriaceae
Escherichia coli
Humans
Ileum
In Situ Hybridization, Fluorescence
Inflammatory Bowel Diseases
Intestinal Mucosa
Male
Mice
Mice, Inbred C57BL
Microscopy, Confocal
Prospective Studies
Retrospective Studies

Access to Document

10.1136/gut.2010.213264

Cite this

Moussata, D., Goetz, M., Gloeckner, A., Kerner, M., Campbell, B., Hoffman, A., Biesterfeld, S., Flourie, B., Saurin, J-C., Galle, P. R., Neurath, M. F., Watson, A. J. M., & Kiesslich, R. (2011). Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo. Gut, 60(1), 26-33. https://doi.org/10.1136/gut.2010.213264

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title = "Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo",

abstract = "Interaction of bacteria with the immune system within the intestinal mucosa plays a key role in the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to develop a fluorescein-aided confocal laser endomicroscopy (CLE) method to visualise intramucosal enteric bacteria in vivo and to determine the involved mucosal area in the colon and ileum in patients with ulcerative colitis (UC) and Crohn's disease (CD).",

keywords = "Animals, Colitis, Ulcerative, Colon, Colonoscopy, Crohn Disease, Enterobacteriaceae, Escherichia coli, Humans, Ileum, In Situ Hybridization, Fluorescence, Inflammatory Bowel Diseases, Intestinal Mucosa, Male, Mice, Mice, Inbred C57BL, Microscopy, Confocal, Prospective Studies, Retrospective Studies",

author = "Driffa Moussata and Martin Goetz and Annabel Gloeckner and Marcus Kerner and Barry Campbell and Arthur Hoffman and Stephan Biesterfeld and Bernard Flourie and Jean-Christophe Saurin and Galle, {Peter R} and Neurath, {Markus F} and Watson, {Alastair J M} and Ralf Kiesslich",

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doi = "10.1136/gut.2010.213264",

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Moussata, D, Goetz, M, Gloeckner, A, Kerner, M, Campbell, B, Hoffman, A, Biesterfeld, S, Flourie, B, Saurin, J-C, Galle, PR, Neurath, MF, Watson, AJM & Kiesslich, R 2011, 'Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo', Gut, vol. 60, no. 1, pp. 26-33. https://doi.org/10.1136/gut.2010.213264

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T1 - Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo

AU - Moussata, Driffa

AU - Goetz, Martin

AU - Gloeckner, Annabel

AU - Kerner, Marcus

AU - Campbell, Barry

AU - Hoffman, Arthur

AU - Biesterfeld, Stephan

AU - Flourie, Bernard

AU - Saurin, Jean-Christophe

AU - Galle, Peter R

AU - Neurath, Markus F

AU - Watson, Alastair J M

AU - Kiesslich, Ralf

PY - 2011/1

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AB - Interaction of bacteria with the immune system within the intestinal mucosa plays a key role in the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to develop a fluorescein-aided confocal laser endomicroscopy (CLE) method to visualise intramucosal enteric bacteria in vivo and to determine the involved mucosal area in the colon and ileum in patients with ulcerative colitis (UC) and Crohn's disease (CD).

KW - Animals

KW - Colitis, Ulcerative

KW - Colon

KW - Colonoscopy

KW - Crohn Disease

KW - Enterobacteriaceae

KW - Escherichia coli

KW - Humans

KW - Ileum

KW - In Situ Hybridization, Fluorescence

KW - Inflammatory Bowel Diseases

KW - Intestinal Mucosa

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Microscopy, Confocal

KW - Prospective Studies

KW - Retrospective Studies

U2 - 10.1136/gut.2010.213264

DO - 10.1136/gut.2010.213264

M3 - Article

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VL - 60

SP - 26

EP - 33

JO - Gut

JF - Gut

SN - 0017-5749

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