Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo

Driffa Moussata, Martin Goetz, Annabel Gloeckner, Marcus Kerner, Barry Campbell, Arthur Hoffman, Stephan Biesterfeld, Bernard Flourie, Jean-Christophe Saurin, Peter R Galle, Markus F Neurath, Alastair J M Watson, Ralf Kiesslich

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94 Citations (Scopus)

Abstract

Interaction of bacteria with the immune system within the intestinal mucosa plays a key role in the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to develop a fluorescein-aided confocal laser endomicroscopy (CLE) method to visualise intramucosal enteric bacteria in vivo and to determine the involved mucosal area in the colon and ileum in patients with ulcerative colitis (UC) and Crohn's disease (CD).
Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalGut
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Animals
  • Colitis, Ulcerative
  • Colon
  • Colonoscopy
  • Crohn Disease
  • Enterobacteriaceae
  • Escherichia coli
  • Humans
  • Ileum
  • In Situ Hybridization, Fluorescence
  • Inflammatory Bowel Diseases
  • Intestinal Mucosa
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Confocal
  • Prospective Studies
  • Retrospective Studies

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