Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the C and S conformations of a bioactive heparin-like hexasaccharide

Angeles Canales, Jesus Angulo, Rafael Ojeda, Marta Bruix, Rosa Fayos, Rosa Lozano, Guillermo Giménez-Gallego, Manuel Martín-Lomas, Pedro M. Nieto, Jesús Jiménez-Barbero

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The first direct NMR determination of the conformation of a conformationally flexible heparin-like hexasaccharide bound to a key receptor, FGF-1, is described. The determination has been based on the use of a C-labeled protein and a regular C sugar. FGF-1 recognizes several conformations of the iduronic moieties of the hexasaccharide. Therefore, this case is different than that described for the controversial recognition of heparin-like saccharides by AT-III, which seems to recognize just one conformation of the iduronic acid residues.
Original languageEnglish
Pages (from-to)5778-5779
Number of pages2
JournalJournal of the American Chemical Society
Issue number16
Publication statusPublished - 27 Apr 2005

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