Connective tissue degeneration: Mechanisms of palmar fascia degeneration (Dupuytren’s disease)

S. Karkampouna, M. Kreulen, M. C. Obdeijn, P. Kloen, A. L. Dorjée, F. Rivellese, A. Chojnowski, I. Clark, Marianna Kruithof-de Julio

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Abstract

Dupuytren’s disease is a connective tissue disorder of the hand causing excessive palmar fascial fibrosis with associated finger contracture and disability. The aetiology of the disease is heterogeneous, with both genetic and environmental components. The connective tissue is abnormally infiltrated by myofibroblasts that deposit collagen and other extracellular matrix proteins. We describe the clinical profile of Dupuytren’s disease along with current therapeutic schemes. Recent findings on molecular and cellular parameters that are dysregulated in Dupuytren’s disease, which may contribute to the onset of the disease, and the role of resident inflammation promoting fibrosis, are highlighted. We review recent literature focusing on non-myofibroblast cell types (stem cell-like cells), their pro-inflammatory and pro-fibrotic role that may account for abnormal wound healing response.
Original languageEnglish
Pages (from-to)133–140
Number of pages8
JournalCurrent Molecular Biology Reports
Volume2
Issue number3
Early online date14 Jul 2016
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Inflammation
  • Dupuytren’s
  • Fibrosis
  • Regeneration
  • Contracture

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