Contemporary glycoconjugation chemistry

Giulia Pergolizzi, Simone Dedola, Robert A. Field

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Glycoproteins are typically expressed in nature with heterogeneous glycan components; understanding glycoprotein structure-function relationships is therefore challenging. This has been the driving force for increasing investigation for glycoconjugation techniques, in order to access homogenous natural glycoproteins and analogues thereof. These tools will be invaluable in efforts to unveil the precise role of each glycan structure. This mini-review provides a critical survey of glycoconjugation methodologies, with an emphasis on more recent progress in the field. Chemical and chemo-enzymatic glycoconjugation methods will be described, along with illustrations of typical applications.

Original languageEnglish
Title of host publicationCarbohydrate Chemistry
Subtitle of host publicationVolume 42
EditorsAmelia Pilar Rauter, Thisbe K. Lindhorst, Yves Queneau
PublisherRoyal Society of Chemistry
Pages1-46
Number of pages46
ISBN (Electronic)9781782625384
DOIs
Publication statusPublished - 2017

Publication series

NameCarbohydrate Chemistry
Volume42
ISSN (Print)2041-353X
ISSN (Electronic)1465-1963

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