Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

Richard Milner; Helen J. Anderson; Rebecca F. Rippon; Jennifer S. Mckay; Robin J. M. Franklin; Mark A. Marchionni; Richard Reynolds; Charles Ffrench-Constant

doi:10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9

Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

Richard Milner, Helen J. Anderson, Rebecca F. Rippon, Jennifer S. Mckay, Robin J. M. Franklin, Mark A. Marchionni, Richard Reynolds, Charles Ffrench-Constant

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

Abstract

We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	Glia
Volume	19
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9
Publication status	Published - Jan 1997

Keywords

basic fibroblast growth factor (bFGF)
glial growth factor-2 (GGF-2)
myelination
neuregulin
platelet derived growth factor (PDGF)
proliferation

Access to Document

10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9

Cite this

@article{9276eb7107b84c099891c590a167efb2,

title = "Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration",

abstract = "We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.",

keywords = "basic fibroblast growth factor (bFGF), glial growth factor-2 (GGF-2), myelination, neuregulin, platelet derived growth factor (PDGF), proliferation",

author = "Richard Milner and Anderson, {Helen J.} and Rippon, {Rebecca F.} and Mckay, {Jennifer S.} and Franklin, {Robin J. M.} and Marchionni, {Mark A.} and Richard Reynolds and Charles Ffrench-Constant",

year = "1997",

month = jan,

doi = "10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9",

language = "English",

volume = "19",

pages = "85--90",

journal = "Glia",

issn = "0894-1491",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

AU - Milner, Richard

AU - Anderson, Helen J.

AU - Rippon, Rebecca F.

AU - Mckay, Jennifer S.

AU - Franklin, Robin J. M.

AU - Marchionni, Mark A.

AU - Reynolds, Richard

AU - Ffrench-Constant, Charles

PY - 1997/1

Y1 - 1997/1

N2 - We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.

AB - We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.

KW - basic fibroblast growth factor (bFGF)

KW - glial growth factor-2 (GGF-2)

KW - myelination

KW - neuregulin

KW - platelet derived growth factor (PDGF)

KW - proliferation

UR - http://www.scopus.com/inward/record.url?scp=0031026857&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9

DO - 10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9

M3 - Article

C2 - 8989571

AN - SCOPUS:0031026857

VL - 19

SP - 85

EP - 90

JO - Glia

JF - Glia

SN - 0894-1491

IS - 1

ER -

Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

Abstract

Keywords

Access to Document

Other files and links

Cite this