Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

Richard Milner, Helen J. Anderson, Rebecca F. Rippon, Jennifer S. Mckay, Robin J. M. Franklin, Mark A. Marchionni, Richard Reynolds, Charles Ffrench-Constant

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalGlia
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 1997

Keywords

  • basic fibroblast growth factor (bFGF)
  • glial growth factor-2 (GGF-2)
  • myelination
  • neuregulin
  • platelet derived growth factor (PDGF)
  • proliferation

Cite this