Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Zoë A. E. Waller, Benjamin J. Pinchbeck, Bhovina Seewoodharry Buguth, Timothy G. Meadows, David J. Richardson, Andrew J. Gates

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Abstract

Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.
Original languageEnglish
Pages (from-to)13511-13514
Number of pages4
JournalChemical Communications
Volume52
Issue number92
Early online date1 Nov 2016
DOIs
Publication statusPublished - 28 Nov 2016

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