Controlling the activities of the diiron centre in bacterial monooxygenases: Lessons from mutagenesis and biodiversity

Tim Nichol, J. Colin Murrell, Thomas J. Smith

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The soluble diiron monooxygenases (SDIMOs) are a diverse group of enzymes that use a diiron active centre to add oxygen to a wide range of organic molecules. Here we review how natural biodiversity and laboratory mutagenesis studies have revealed how the protein scaffold of SDIMOs controls the activity of the enzymes and the presentation of substrates to the diiron site.
Original languageEnglish
Pages (from-to)3419-3431
Number of pages13
JournalEuropean Journal of Inorganic Chemistry
Issue number21
Early online date2 Apr 2015
Publication statusPublished - Jul 2015

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