Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial

K M John Chan, Prakash P Punjabi, Marcus Flather, Riccardo Wage, Karen Symmonds, Isabelle Roussin, Shelley Rahman-Haley, Dudley J Pennell, Philip J Kilner, Gilles D Dreyfus, John R Pepper, RIME Investigators

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270 Citations (Scopus)


The role of mitral valve repair (MVR) during coronary artery bypass grafting (CABG) in patients with moderate ischemic mitral regurgitation (MR) is uncertain. We conducted a randomized, controlled trial to determine whether repairing the mitral valve during CABG may improve functional capacity and left ventricular reverse remodeling compared with CABG alone.
Original languageEnglish
Pages (from-to)2502-2510
Number of pages9
Issue number21
Publication statusPublished - 20 Nov 2012


  • Humans
  • Myocardial Ischemia
  • Aged
  • Single-Blind Method
  • Aged, 80 and over
  • Coronary Artery Bypass
  • Treatment Outcome
  • Follow-Up Studies
  • Middle Aged
  • Mitral Valve Annuloplasty
  • Female
  • Male
  • Mitral Valve Insufficiency
  • Coronary disease
  • Mitral valve regurgitation
  • surgery

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