Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial

K M John Chan; Prakash P Punjabi; Marcus Flather; Riccardo Wage; Karen Symmonds; Isabelle Roussin; Shelley Rahman-Haley; Dudley J Pennell; Philip J Kilner; Gilles D Dreyfus; John R Pepper; RIME Investigators

doi:10.1161/CIRCULATIONAHA.112.143818

Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial

K M John Chan, Prakash P Punjabi, Marcus Flather, Riccardo Wage, Karen Symmonds, Isabelle Roussin, Shelley Rahman-Haley, Dudley J Pennell, Philip J Kilner, Gilles D Dreyfus, John R Pepper, RIME Investigators

Research output: Contribution to journal › Article › peer-review

275 Citations (Scopus)

Abstract

The role of mitral valve repair (MVR) during coronary artery bypass grafting (CABG) in patients with moderate ischemic mitral regurgitation (MR) is uncertain. We conducted a randomized, controlled trial to determine whether repairing the mitral valve during CABG may improve functional capacity and left ventricular reverse remodeling compared with CABG alone.

Original language	English
Pages (from-to)	2502-2510
Number of pages	9
Journal	Circulation
Volume	126
Issue number	21
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.112.143818
Publication status	Published - 20 Nov 2012

Keywords

Humans
Myocardial Ischemia
Aged
Single-Blind Method
Aged, 80 and over
Coronary Artery Bypass
Treatment Outcome
Follow-Up Studies
Middle Aged
Mitral Valve Annuloplasty
Female
Male
Mitral Valve Insufficiency
Coronary disease
Mitral valve regurgitation
surgery

Access to Document

10.1161/CIRCULATIONAHA.112.143818

Cite this

Chan, K. M. J., Punjabi, P. P., Flather, M., Wage, R., Symmonds, K., Roussin, I., Rahman-Haley, S., Pennell, D. J., Kilner, P. J., Dreyfus, G. D., Pepper, J. R., & RIME Investigators (2012). Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial. Circulation, 126(21), 2502-2510. https://doi.org/10.1161/CIRCULATIONAHA.112.143818

Chan, K M John ; Punjabi, Prakash P ; Flather, Marcus ; Wage, Riccardo ; Symmonds, Karen ; Roussin, Isabelle ; Rahman-Haley, Shelley ; Pennell, Dudley J ; Kilner, Philip J ; Dreyfus, Gilles D ; Pepper, John R ; RIME Investigators. / Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation : final results of the Randomized Ischemic Mitral Evaluation (RIME) trial. In: Circulation. 2012 ; Vol. 126, No. 21. pp. 2502-2510.

@article{97e3364f63264c6aa80cac1c122ec90e,

title = "Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial",

abstract = "The role of mitral valve repair (MVR) during coronary artery bypass grafting (CABG) in patients with moderate ischemic mitral regurgitation (MR) is uncertain. We conducted a randomized, controlled trial to determine whether repairing the mitral valve during CABG may improve functional capacity and left ventricular reverse remodeling compared with CABG alone.",

keywords = "Humans, Myocardial Ischemia, Aged, Single-Blind Method, Aged, 80 and over, Coronary Artery Bypass, Treatment Outcome, Follow-Up Studies, Middle Aged, Mitral Valve Annuloplasty, Female, Male, Mitral Valve Insufficiency, Coronary disease, Mitral valve regurgitation, surgery",

author = "Chan, {K M John} and Punjabi, {Prakash P} and Marcus Flather and Riccardo Wage and Karen Symmonds and Isabelle Roussin and Shelley Rahman-Haley and Pennell, {Dudley J} and Kilner, {Philip J} and Dreyfus, {Gilles D} and Pepper, {John R} and {RIME Investigators}",

year = "2012",

month = nov,

day = "20",

doi = "10.1161/CIRCULATIONAHA.112.143818",

language = "English",

volume = "126",

pages = "2502--2510",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott, Williams and Wilkins",

number = "21",

}

Chan, KMJ, Punjabi, PP, Flather, M, Wage, R, Symmonds, K, Roussin, I, Rahman-Haley, S, Pennell, DJ, Kilner, PJ, Dreyfus, GD, Pepper, JR & RIME Investigators 2012, 'Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized Ischemic Mitral Evaluation (RIME) trial', Circulation, vol. 126, no. 21, pp. 2502-2510. https://doi.org/10.1161/CIRCULATIONAHA.112.143818

Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation : final results of the Randomized Ischemic Mitral Evaluation (RIME) trial. / Chan, K M John; Punjabi, Prakash P; Flather, Marcus; Wage, Riccardo; Symmonds, Karen; Roussin, Isabelle; Rahman-Haley, Shelley; Pennell, Dudley J; Kilner, Philip J; Dreyfus, Gilles D; Pepper, John R; RIME Investigators.

In: Circulation, Vol. 126, No. 21, 20.11.2012, p. 2502-2510.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Coronary artery bypass surgery with or without mitral valve annuloplasty in moderate functional ischemic mitral regurgitation

T2 - final results of the Randomized Ischemic Mitral Evaluation (RIME) trial

AU - Chan, K M John

AU - Punjabi, Prakash P

AU - Flather, Marcus

AU - Wage, Riccardo

AU - Symmonds, Karen

AU - Roussin, Isabelle

AU - Rahman-Haley, Shelley

AU - Pennell, Dudley J

AU - Kilner, Philip J

AU - Dreyfus, Gilles D

AU - Pepper, John R

AU - RIME Investigators

PY - 2012/11/20

Y1 - 2012/11/20

N2 - The role of mitral valve repair (MVR) during coronary artery bypass grafting (CABG) in patients with moderate ischemic mitral regurgitation (MR) is uncertain. We conducted a randomized, controlled trial to determine whether repairing the mitral valve during CABG may improve functional capacity and left ventricular reverse remodeling compared with CABG alone.

AB - The role of mitral valve repair (MVR) during coronary artery bypass grafting (CABG) in patients with moderate ischemic mitral regurgitation (MR) is uncertain. We conducted a randomized, controlled trial to determine whether repairing the mitral valve during CABG may improve functional capacity and left ventricular reverse remodeling compared with CABG alone.

KW - Humans

KW - Myocardial Ischemia

KW - Aged

KW - Single-Blind Method

KW - Aged, 80 and over

KW - Coronary Artery Bypass

KW - Treatment Outcome

KW - Follow-Up Studies

KW - Middle Aged

KW - Mitral Valve Annuloplasty

KW - Female

KW - Male

KW - Mitral Valve Insufficiency

KW - Coronary disease

KW - Mitral valve regurgitation

KW - surgery

U2 - 10.1161/CIRCULATIONAHA.112.143818

DO - 10.1161/CIRCULATIONAHA.112.143818

M3 - Article

C2 - 23136163

VL - 126

SP - 2502

EP - 2510

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 21

ER -