CPMV-DOX Delivers

Alaa A. A. Aljabali, Sourabh Shukla, George P. Lomonossoff, Nicole F. Steinmetz, David J. Evans

Research output: Contribution to journalArticlepeer-review

107 Citations (Scopus)

Abstract

The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.
Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalMolecular Pharmaceutics
Volume10
Issue number1
Early online date24 Jul 2012
DOIs
Publication statusPublished - 7 Jan 2013

Keywords

  • cancer
  • Cowpea mosaic virus
  • doxorubicin
  • drug delivery
  • viral nanoparticle

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