Crohn's disease: the cold chain hypothesis

Alastair Forbes, Tommy Kalantzis

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


A recent published hypothesis proposed that Crohn's disease was provoked by infantile exposure to micro-organisms that can survive refrigerator temperature. A case-control study was accordingly devised. The mean age at first fridge was 5.6 years amongst 88 patients with Crohn's disease, 5.5 years in 88 patients with ulcerative colitis (UC) and 7.6 years in 88 controls, but a majority of individuals had always been exposed to refrigerated food. Differences were more striking in subjects aged above the median (10.3, 10.9 and 15.0 years for Crohn's disease, UC and controls, respectively). This support for the hypothesis reached statistical significance for those with Crohn's disease compared to the controls (p=0.045).
Original languageEnglish
Pages (from-to)399-401
Number of pages3
JournalInternational Journal of Colorectal Disease
Issue number5
Publication statusPublished - Jul 2006


  • Adolescent
  • Adult
  • Bacteria
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Crohn Disease
  • Female
  • Food Microbiology
  • Humans
  • Male
  • Refrigeration

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