CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Edward S. Hems, Ben A. Wagstaff, Gerhard Saalbach, Robert A. Field

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
14 Downloads (Pure)


In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.
Original languageEnglish
Pages (from-to)12234-12237
JournalChemical Communications
Issue number86
Early online date12 Oct 2018
Publication statusPublished - 7 Nov 2018

Cite this