CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Edward S. Hems; Ben A. Wagstaff; Gerhard Saalbach; Robert A. Field

doi:10.1039/C8CC05113E

CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Edward S. Hems
, Ben A. Wagstaff
, Gerhard Saalbach
, Robert A. Field

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

21 Downloads (Pure)

Abstract

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

Original language	English
Pages (from-to)	12234-12237
Journal	Chemical Communications
Volume	54
Issue number	86
Early online date	12 Oct 2018
DOIs	https://doi.org/10.1039/C8CC05113E
Publication status	Published - 7 Nov 2018

Access to Document

10.1039/C8CC05113ELicence: CC BY

Published manuscript
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Final published version, 2.13 MBLicence: CC BY

http://xlink.rsc.org/?DOI=C8CC05113ELicence: CC BY

Cite this

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abstract = "In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.",

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AB - In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

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