Cysteine peptidases of kinetoplastid parasites

Dietmar Steverding, Conor R. Caffrey, Ana-Paule Lima

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage‑specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host’s immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.
Original languageEnglish
Pages (from-to)84-99
Number of pages16
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 2011

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