Abstract
We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage‑specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host’s immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.
Original language | English |
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Pages (from-to) | 84-99 |
Number of pages | 16 |
Journal | Advances in Experimental Medicine and Biology |
Volume | 712 |
DOIs | |
Publication status | Published - 2011 |