TY - JOUR
T1 - Cytotoxic constituents from the wheat plant pathogen Parastagonospora nodorum SN15
AU - El-Demerdash, Amr
AU - Borde, Chloé
AU - Genta-Jouve, Gregory
AU - Escargueil, Alexandre
AU - Prado, Soizic
N1 - Funding Information:
This work was supported by the Action Transversal from the Natural History Museum of Paris. The 400 MHz and 600 MHz NMR spectrometers used in this study were funded jointly by the Région Ile-de-France, the MNHN (Paris, France) and the CNRS (France).
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Microbial natural products are continuing to be a promising platform for future drug lead discover. As a part of our ongoing research program on fungal natural product, herein we report metabolites isolated from the fungus Parastagonospora nodorum SN15 a pathogen of wheat and related cereals. Its chemical investigation led to the purification of new isoleucinic acid derivatives (1–2) along with the cis procuramine (4). Their structures were determined based on extensive NMR and the relative configuration by comparison of experimental and predicted NMR chemical shifts. All compounds were evaluated for their cytotoxic activity against a panel of human cell lines and some displayed specific feature towards cancer cells compared to normal immortalised fibroblasts. (Figure presented.).
AB - Microbial natural products are continuing to be a promising platform for future drug lead discover. As a part of our ongoing research program on fungal natural product, herein we report metabolites isolated from the fungus Parastagonospora nodorum SN15 a pathogen of wheat and related cereals. Its chemical investigation led to the purification of new isoleucinic acid derivatives (1–2) along with the cis procuramine (4). Their structures were determined based on extensive NMR and the relative configuration by comparison of experimental and predicted NMR chemical shifts. All compounds were evaluated for their cytotoxic activity against a panel of human cell lines and some displayed specific feature towards cancer cells compared to normal immortalised fibroblasts. (Figure presented.).
KW - cytotoxicity
KW - indolizine alkaloids
KW - isoleucinic acids derivatives
KW - Parastagonospora nodorum
UR - http://www.scopus.com/inward/record.url?scp=85101040331&partnerID=8YFLogxK
U2 - 10.1080/14786419.2021.1877702
DO - 10.1080/14786419.2021.1877702
M3 - Article
C2 - 33605174
AN - SCOPUS:85101040331
VL - 36
SP - 1273
EP - 1281
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
IS - 5
ER -
