TY - JOUR
T1 - Cytotoxicity of ruthenium(II) arene complexes containing functionalized ferrocenyl β-diketonate ligands
AU - Allison, Matthew
AU - Caramés-Méndez, Pablo
AU - Hofmann, Benjamin J.
AU - Pask, Christopher M.
AU - Phillips, Roger M.
AU - Lord, Rianne M.
AU - McGowan, Patrick C.
PY - 2023/8/14
Y1 - 2023/8/14
N2 - The synthesis and characterization of 24 ruthenium(II) arene complexes of the type [(p-cym)RuCl(Fc-acac)] (where p-cym = p-cymene and Fc-acac = functionalized ferrocenyl β-diketonate ligands) are reported, including single-crystal X-ray diffraction for 21 new complexes. Chemosensitivity studies have been conducted against human pancreatic carcinoma (MIA PaCa-2), human colorectal adenocarcinoma p53-wildtype (HCT116 p53+/+) and normal human retinal epithelial cell lines (APRE-19). The most active complex, which contains a 2-furan-substituted ligand (4), is 5x more cytotoxic than the analogs 3-furan complex (5) against MIA PaCa-2. Several complexes were screened under hypoxic conditions and at shorter-time incubations, and their ability to damage DNA was determined by the comet assay. Compounds were also screened for their potential to inhibit the growth of both bacterial and fungal strains.
AB - The synthesis and characterization of 24 ruthenium(II) arene complexes of the type [(p-cym)RuCl(Fc-acac)] (where p-cym = p-cymene and Fc-acac = functionalized ferrocenyl β-diketonate ligands) are reported, including single-crystal X-ray diffraction for 21 new complexes. Chemosensitivity studies have been conducted against human pancreatic carcinoma (MIA PaCa-2), human colorectal adenocarcinoma p53-wildtype (HCT116 p53+/+) and normal human retinal epithelial cell lines (APRE-19). The most active complex, which contains a 2-furan-substituted ligand (4), is 5x more cytotoxic than the analogs 3-furan complex (5) against MIA PaCa-2. Several complexes were screened under hypoxic conditions and at shorter-time incubations, and their ability to damage DNA was determined by the comet assay. Compounds were also screened for their potential to inhibit the growth of both bacterial and fungal strains.
UR - http://www.scopus.com/inward/record.url?scp=85164721614&partnerID=8YFLogxK
U2 - 10.1021/acs.organomet.2c00553
DO - 10.1021/acs.organomet.2c00553
M3 - Article
VL - 42
SP - 1869
EP - 1881
JO - Organometallics
JF - Organometallics
SN - 0276-7333
IS - 15
ER -