Death and dying in heart failure with normal ejection fraction

Hoong Sern Lim, Roger Beadle, Michael Frenneaux

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5 Citations (Scopus)


The overall mortality rate in patients with heart failure with normal ejection fraction (HFNEF) appears to be comparable to that in patients with heart failure with reduced ejection fraction. In contrast to the latter group of patients, randomized trials with neurohumoral blockade in patients with HFNEF have failed to demonstrate reduction in mortality. This is at least in part related to the lower proportion of heart failure-related death in the overall population of patients with HFNEF. In conclusion, better characterization of patients with HFNEF at greatest risk for heart failure-related death and understanding the risks of the different modes of death would allow more effective use of specific heart failure medical or device therapy in patients with HFNEF.
Original languageEnglish
Pages (from-to)1311-1314
Number of pages4
JournalThe American Journal of Cardiology
Issue number9
Publication statusPublished - 1 Nov 2009


  • Heart Failure
  • Humans
  • Stroke Volume

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