Death and dying in heart failure with normal ejection fraction

Hoong Sern Lim; Roger Beadle; Michael Frenneaux

doi:10.1016/j.amjcard.2009.06.050

Death and dying in heart failure with normal ejection fraction

Hoong Sern Lim, Roger Beadle, Michael Frenneaux

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The overall mortality rate in patients with heart failure with normal ejection fraction (HFNEF) appears to be comparable to that in patients with heart failure with reduced ejection fraction. In contrast to the latter group of patients, randomized trials with neurohumoral blockade in patients with HFNEF have failed to demonstrate reduction in mortality. This is at least in part related to the lower proportion of heart failure-related death in the overall population of patients with HFNEF. In conclusion, better characterization of patients with HFNEF at greatest risk for heart failure-related death and understanding the risks of the different modes of death would allow more effective use of specific heart failure medical or device therapy in patients with HFNEF.

Original language	English
Pages (from-to)	1311-1314
Number of pages	4
Journal	The American Journal of Cardiology
Volume	104
Issue number	9
DOIs	https://doi.org/10.1016/j.amjcard.2009.06.050
Publication status	Published - 1 Nov 2009

Keywords

Heart Failure
Humans
Stroke Volume

Access to Document

10.1016/j.amjcard.2009.06.050

Cite this

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title = "Death and dying in heart failure with normal ejection fraction",

abstract = "The overall mortality rate in patients with heart failure with normal ejection fraction (HFNEF) appears to be comparable to that in patients with heart failure with reduced ejection fraction. In contrast to the latter group of patients, randomized trials with neurohumoral blockade in patients with HFNEF have failed to demonstrate reduction in mortality. This is at least in part related to the lower proportion of heart failure-related death in the overall population of patients with HFNEF. In conclusion, better characterization of patients with HFNEF at greatest risk for heart failure-related death and understanding the risks of the different modes of death would allow more effective use of specific heart failure medical or device therapy in patients with HFNEF.",

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T1 - Death and dying in heart failure with normal ejection fraction

AU - Lim, Hoong Sern

AU - Beadle, Roger

AU - Frenneaux, Michael

PY - 2009/11/1

Y1 - 2009/11/1

N2 - The overall mortality rate in patients with heart failure with normal ejection fraction (HFNEF) appears to be comparable to that in patients with heart failure with reduced ejection fraction. In contrast to the latter group of patients, randomized trials with neurohumoral blockade in patients with HFNEF have failed to demonstrate reduction in mortality. This is at least in part related to the lower proportion of heart failure-related death in the overall population of patients with HFNEF. In conclusion, better characterization of patients with HFNEF at greatest risk for heart failure-related death and understanding the risks of the different modes of death would allow more effective use of specific heart failure medical or device therapy in patients with HFNEF.

AB - The overall mortality rate in patients with heart failure with normal ejection fraction (HFNEF) appears to be comparable to that in patients with heart failure with reduced ejection fraction. In contrast to the latter group of patients, randomized trials with neurohumoral blockade in patients with HFNEF have failed to demonstrate reduction in mortality. This is at least in part related to the lower proportion of heart failure-related death in the overall population of patients with HFNEF. In conclusion, better characterization of patients with HFNEF at greatest risk for heart failure-related death and understanding the risks of the different modes of death would allow more effective use of specific heart failure medical or device therapy in patients with HFNEF.

KW - Heart Failure

KW - Humans

KW - Stroke Volume

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DO - 10.1016/j.amjcard.2009.06.050

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JO - American Journal of Cardiology

JF - American Journal of Cardiology

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IS - 9

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