Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007

Matthew J. Ellington, Russell Hope, David M. Livermore, Angela M. Kearns, Katherine Henderson, Barry D. Cookson, Andrew Pearson, Alan P. Johnson

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)


Objectives Between 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% and 35.4%, respectively). We sought to determine the proportions of these strains before and after the general decline in MRSA bacteraemia that began around 2004. Methods Consecutive MRSA isolates collected in 2001, 2003, 2005 and 2007 by the BSAC Bacteraemia Surveillance Programme were categorized to multilocus sequence typing (MLST) clonal complex and to SCCmec type by PCR. MICs were determined by the BSAC method. Data trends were tested for significance using a generalized linear regression model. Results Collectively, EMRSA-15 and EMRSA-16 consistently accounted for ~95% of MRSA studied between 2001 and 2007, but the proportions of EMRSA-16 declined from 21.4% in 2001 to 9% in 2007 (P?
Original languageEnglish
Pages (from-to)446-448
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Issue number3
Publication statusPublished - Mar 2010

Cite this