Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007

Matthew J. Ellington; Russell Hope; David M. Livermore; Angela M. Kearns; Katherine Henderson; Barry D. Cookson; Andrew Pearson; Alan P. Johnson

doi:10.1093/jac/dkp448

Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007

Matthew J. Ellington, Russell Hope, David M. Livermore, Angela M. Kearns, Katherine Henderson, Barry D. Cookson, Andrew Pearson, Alan P. Johnson

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

Objectives Between 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% and 35.4%, respectively). We sought to determine the proportions of these strains before and after the general decline in MRSA bacteraemia that began around 2004. Methods Consecutive MRSA isolates collected in 2001, 2003, 2005 and 2007 by the BSAC Bacteraemia Surveillance Programme were categorized to multilocus sequence typing (MLST) clonal complex and to SCCmec type by PCR. MICs were determined by the BSAC method. Data trends were tested for significance using a generalized linear regression model. Results Collectively, EMRSA-15 and EMRSA-16 consistently accounted for ~95% of MRSA studied between 2001 and 2007, but the proportions of EMRSA-16 declined from 21.4% in 2001 to 9% in 2007 (P?

Original language	English
Pages (from-to)	446-448
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	65
Issue number	3
DOIs	https://doi.org/10.1093/jac/dkp448
Publication status	Published - Mar 2010

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10.1093/jac/dkp448

Cite this

@article{948035f9b31a4771bd6b8d5220bbc584,

title = "Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007",

abstract = "Objectives Between 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% and 35.4%, respectively). We sought to determine the proportions of these strains before and after the general decline in MRSA bacteraemia that began around 2004. Methods Consecutive MRSA isolates collected in 2001, 2003, 2005 and 2007 by the BSAC Bacteraemia Surveillance Programme were categorized to multilocus sequence typing (MLST) clonal complex and to SCCmec type by PCR. MICs were determined by the BSAC method. Data trends were tested for significance using a generalized linear regression model. Results Collectively, EMRSA-15 and EMRSA-16 consistently accounted for ~95% of MRSA studied between 2001 and 2007, but the proportions of EMRSA-16 declined from 21.4% in 2001 to 9% in 2007 (P?",

author = "Ellington, {Matthew J.} and Russell Hope and Livermore, {David M.} and Kearns, {Angela M.} and Katherine Henderson and Cookson, {Barry D.} and Andrew Pearson and Johnson, {Alan P.}",

year = "2010",

month = mar,

doi = "10.1093/jac/dkp448",

language = "English",

volume = "65",

pages = "446--448",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Decline of EMRSA-16 amongst methicillin-resistant Staphylococcus aureus causing bacteraemias in the UK between 2001 and 2007

AU - Ellington, Matthew J.

AU - Hope, Russell

AU - Livermore, David M.

AU - Kearns, Angela M.

AU - Henderson, Katherine

AU - Cookson, Barry D.

AU - Pearson, Andrew

AU - Johnson, Alan P.

PY - 2010/3

Y1 - 2010/3

N2 - Objectives Between 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% and 35.4%, respectively). We sought to determine the proportions of these strains before and after the general decline in MRSA bacteraemia that began around 2004. Methods Consecutive MRSA isolates collected in 2001, 2003, 2005 and 2007 by the BSAC Bacteraemia Surveillance Programme were categorized to multilocus sequence typing (MLST) clonal complex and to SCCmec type by PCR. MICs were determined by the BSAC method. Data trends were tested for significance using a generalized linear regression model. Results Collectively, EMRSA-15 and EMRSA-16 consistently accounted for ~95% of MRSA studied between 2001 and 2007, but the proportions of EMRSA-16 declined from 21.4% in 2001 to 9% in 2007 (P?

AB - Objectives Between 1998 and 2000, 95.6% of methicillin-resistant Staphylococcus aureus (MRSA) bacteraemias in the UK were due to two epidemic strains, namely EMRSA-15 or EMRSA-16 (60.2% and 35.4%, respectively). We sought to determine the proportions of these strains before and after the general decline in MRSA bacteraemia that began around 2004. Methods Consecutive MRSA isolates collected in 2001, 2003, 2005 and 2007 by the BSAC Bacteraemia Surveillance Programme were categorized to multilocus sequence typing (MLST) clonal complex and to SCCmec type by PCR. MICs were determined by the BSAC method. Data trends were tested for significance using a generalized linear regression model. Results Collectively, EMRSA-15 and EMRSA-16 consistently accounted for ~95% of MRSA studied between 2001 and 2007, but the proportions of EMRSA-16 declined from 21.4% in 2001 to 9% in 2007 (P?

U2 - 10.1093/jac/dkp448

DO - 10.1093/jac/dkp448

M3 - Article

VL - 65

SP - 446

EP - 448

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 3

ER -