Defects in the origin licensing checkpoint stresses cells exiting G0

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Abstract

The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.
Original languageEnglish
Pages (from-to)2080-2081
Number of pages2
JournalJournal of Cell Biology
Volume218
Issue number7
Early online date11 Jun 2019
DOIs
Publication statusPublished - 1 Jul 2019

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