Defects in the origin licensing checkpoint stresses cells exiting G0

J. Julian Blow

doi:10.1083/jcb.201905181

Defects in the origin licensing checkpoint stresses cells exiting G0

J. Julian Blow

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Abstract

The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.

Original language	English
Pages (from-to)	2080-2081
Number of pages	2
Journal	Journal of Cell Biology
Volume	218
Issue number	7
Early online date	11 Jun 2019
DOIs	https://doi.org/10.1083/jcb.201905181
Publication status	Published - 1 Jul 2019

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Cite this

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title = "Defects in the origin licensing checkpoint stresses cells exiting G0",

abstract = "The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.",

author = "Blow, \{J. Julian\}",

note = "Funding: Wellcome Trust WT096598MA",

year = "2019",

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N2 - The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.

AB - The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.

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DO - 10.1083/jcb.201905181

M3 - Article

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