Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Khuloud T Al-Jamal; Antonio Nunes; Laura Methven; Hanene Ali-Boucetta; Shouping Li; Francesca M Toma; M Antonia Herrero; Wafa' T Al-Jamal; Huub M M ten Eikelder; Julie Foster; Stephen Mather; Maurizio Prato; Alberto Bianco; Kostas Kostarelos

doi:10.1002/anie.201201991

Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Khuloud T Al-Jamal, Antonio Nunes, Laura Methven, Hanene Ali-Boucetta, Shouping Li, Francesca M Toma, M Antonia Herrero, Wafa' T Al-Jamal, Huub M M ten Eikelder, Julie Foster, Stephen Mather, Maurizio Prato, Alberto Bianco, Kostas Kostarelos

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

Original language	English
Pages (from-to)	6389-6393
Number of pages	5
Journal	Angewandte Chemie-International Edition
Volume	51
Issue number	26
DOIs	https://doi.org/10.1002/anie.201201991
Publication status	Published - 25 Jun 2012

Keywords

Molecular Structure
Microscopy, Electron, Transmission
Animals
Models, Molecular
Organ Specificity
Mice
Amines
Nanotubes, Carbon

Access to Document

10.1002/anie.201201991

Cite this

Al-Jamal, K. T., Nunes, A., Methven, L., Ali-Boucetta, H., Li, S., Toma, F. M., Herrero, M. A., Al-Jamal, W. T., ten Eikelder, H. M. M., Foster, J., Mather, S., Prato, M., Bianco, A., & Kostarelos, K. (2012). Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile. Angewandte Chemie-International Edition, 51(26), 6389-6393. https://doi.org/10.1002/anie.201201991

Al-Jamal, Khuloud T ; Nunes, Antonio ; Methven, Laura ; Ali-Boucetta, Hanene ; Li, Shouping ; Toma, Francesca M ; Herrero, M Antonia ; Al-Jamal, Wafa' T ; ten Eikelder, Huub M M ; Foster, Julie ; Mather, Stephen ; Prato, Maurizio ; Bianco, Alberto ; Kostarelos, Kostas. / Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile. In: Angewandte Chemie-International Edition. 2012 ; Vol. 51, No. 26. pp. 6389-6393.

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title = "Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile",

abstract = "Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.",

keywords = "Molecular Structure, Microscopy, Electron, Transmission, Animals, Models, Molecular, Organ Specificity, Mice, Amines, Nanotubes, Carbon",

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year = "2012",

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Al-Jamal, KT, Nunes, A, Methven, L, Ali-Boucetta, H, Li, S, Toma, FM, Herrero, MA, Al-Jamal, WT, ten Eikelder, HMM, Foster, J, Mather, S, Prato, M, Bianco, A & Kostarelos, K 2012, 'Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile', Angewandte Chemie-International Edition, vol. 51, no. 26, pp. 6389-6393. https://doi.org/10.1002/anie.201201991

Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile. / Al-Jamal, Khuloud T; Nunes, Antonio; Methven, Laura; Ali-Boucetta, Hanene; Li, Shouping; Toma, Francesca M; Herrero, M Antonia; Al-Jamal, Wafa' T; ten Eikelder, Huub M M; Foster, Julie; Mather, Stephen; Prato, Maurizio; Bianco, Alberto; Kostarelos, Kostas.

In: Angewandte Chemie-International Edition, Vol. 51, No. 26, 25.06.2012, p. 6389-6393.

Research output: Contribution to journal › Article › peer-review

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KW - Microscopy, Electron, Transmission

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KW - Models, Molecular

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