Delayed acetyl-L-carnitine administration and its effect on sensory neuronal rescue after peripheral nerve injury

Andrew D H Wilson, Andrew Hart, Thomas Brännström, Mikael Wiberg, Giorgio Terenghi

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42 Citations (Scopus)


Protection of sensory neurons after peripheral nerve injury is clinically crucial since inadequate sensory recovery is seriously affected by the death of up to 40% of sensory neurons. Immediate acetyl-L-carnitine (ALCAR) treatment eliminates this cell loss, but may not always be clinically feasible, hence we studied the effect of delaying the initiation of ALCAR treatment. Five groups of rats (n=5 per group) underwent unilateral sciatic nerve axotomy. ALCAR treatment (50 mg/kg/day) was initiated immediately, or after delays of 6 h, 24 h or 7 days after injury. A sham-treated group served as control. L4 and L5 dorsal root ganglia were harvested bilaterally 2 weeks after injury and stereological sensory neuron counts were obtained. Immediate sham treatment provided no neuroprotection (25% loss). Cell loss was eliminated when ALCAR was commenced within
Original languageEnglish
Pages (from-to)114-8
Number of pages5
JournalJournal of Plastic, Reconstructive & Aesthetic Surgery
Issue number2
Publication statusPublished - 2007


  • Acetylcarnitine
  • Animals
  • Axotomy
  • Cell Count
  • Ganglia, Spinal
  • Injections, Intraperitoneal
  • Lumbar Vertebrae
  • Neurons, Afferent
  • Neuroprotective Agents
  • Rats
  • Rats, Sprague-Dawley
  • Sciatic Nerve
  • Time Factors

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