Delineation of the function of a major gamma delta T cell subset during infection

Elizabeth M. Andrew, Darren J. Newton, Jane E. Dalton, Charlotte E. Egan, Stewart J. Goodwin, Daniela Tramonti, Philip Scott, Simon R. Carding

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Gammadelta T cells play important but poorly defined roles in pathogen-induced immune responses and in preventing chronic inflammation and pathology. A major obstacle to defining their function is establishing the degree of functional redundancy and heterogeneity among gammadelta T cells. Using mice deficient in Vgamma1+ T cells which are a major component of the gammadelta T cell response to microbial infection, a specific immunoregulatory role for Vgamma1+ T cells in macrophage and gammadelta T cell homeostasis during infection has been established. By contrast, Vgamma1+ T cells play no significant role in pathogen containment or eradication and cannot protect mice from immune-mediated pathology. Pathogen-elicited Vgamma1+ T cells also display different functional characteristics at different stages of the host response to infection that involves unique and different populations of Vgamma1+ T cells. These findings, therefore, identify distinct and nonoverlapping roles for gammadelta T cell subsets in infection and establish the complexity and adaptability of a single population of gammadelta T cells in the host response to infection that is not predetermined, but is, instead, shaped by environmental factors.
Original languageEnglish
Pages (from-to)1741-1750
Number of pages10
JournalJournal of Immunology
Issue number3
Publication statusPublished - 1 Aug 2005

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