Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics

S S Lele; S T Durrant; J J Atherton; T D Moore; H L Thomson; F A Khafagi; M P Frenneaux

Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics

S S Lele, S T Durrant, J J Atherton, T D Moore, H L Thomson, F A Khafagi, M P Frenneaux

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Abstract

We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy. Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PFR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 +/- 65 vs 131 +/- 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 +/- 40 vs 54 +/- 19 ms, P

Original language	English
Pages (from-to)	1113-1118
Number of pages	6
Journal	Bone Marrow Transplantation
Volume	17
Issue number	6
Publication status	Published - Jun 1996

Keywords

Adult
Bone Marrow Transplantation
Cyclophosphamide
Diastole
Exercise Test
Female
Humans
Male
Middle Aged
Transplantation Conditioning
Ventricular Function, Left

Cite this

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title = "Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics",

abstract = "We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy. Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PFR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 +/- 65 vs 131 +/- 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 +/- 40 vs 54 +/- 19 ms, P ",

keywords = "Adult, Bone Marrow Transplantation, Cyclophosphamide, Diastole, Exercise Test, Female, Humans, Male, Middle Aged, Transplantation Conditioning, Ventricular Function, Left",

author = "Lele, {S S} and Durrant, {S T} and Atherton, {J J} and Moore, {T D} and Thomson, {H L} and Khafagi, {F A} and Frenneaux, {M P}",

year = "1996",

month = jun,

language = "English",

volume = "17",

pages = "1113--1118",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics

AU - Lele, S S

AU - Durrant, S T

AU - Atherton, J J

AU - Moore, T D

AU - Thomson, H L

AU - Khafagi, F A

AU - Frenneaux, M P

PY - 1996/6

Y1 - 1996/6

N2 - We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy. Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PFR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 +/- 65 vs 131 +/- 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 +/- 40 vs 54 +/- 19 ms, P

AB - We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy. Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PFR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 +/- 65 vs 131 +/- 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 +/- 40 vs 54 +/- 19 ms, P

KW - Adult

KW - Bone Marrow Transplantation

KW - Cyclophosphamide

KW - Diastole

KW - Exercise Test

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Transplantation Conditioning

KW - Ventricular Function, Left

M3 - Article

C2 - 8807123

VL - 17

SP - 1113

EP - 1118

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 6

ER -