Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics

S S Lele, S T Durrant, J J Atherton, T D Moore, H L Thomson, F A Khafagi, M P Frenneaux

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We evaluated the role of rest and exercise left ventricular diastolic filling parameters as a marker of cardiotoxicity in 25 consecutive patients 1 year following BMT. Ten age- and sex-matched subjects served as controls. Patients were evaluated in toto and in three sub-groups according to chemotherapy. Left ventricular ejection fraction (EF), peak filling rate (PFR) and time to peak filling (TTPF) were assessed at rest and at peak exercise. EF and PFR were similar at rest and at peak exercise in patients and controls. TTPF was significantly prolonged at rest in patients compared to controls (200 +/- 65 vs 131 +/- 26 ms, P = 0.003) and at peak exercise was markedly longer in patients (142 +/- 40 vs 54 +/- 19 ms, P
Original languageEnglish
Pages (from-to)1113-1118
Number of pages6
JournalBone Marrow Transplantation
Issue number6
Publication statusPublished - Jun 1996


  • Adult
  • Bone Marrow Transplantation
  • Cyclophosphamide
  • Diastole
  • Exercise Test
  • Female
  • Humans
  • Male
  • Middle Aged
  • Transplantation Conditioning
  • Ventricular Function, Left

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