Denatured muscle grafts for nerve repair. An experimental model of nerve damage in leprosy

J.H. Pereira, S.A. Cowley, S.E. Gschmeissner, R.E.M. Bowden, J.L. Turk

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12 Citations (Scopus)


About 20% of patients with leprosy develop localised granulomatous lesions in peripheral nerves. We report experiments in guinea-pigs in which freeze-thawed autogenis muscle grafts were used for the treatment of such mycobacterial granulomas. Granulomas were induced in guinea-pig tibial nerves and the animals were left for 7 to 100 days in order to assess maximal damage. The local area of nerve damage was then excised and the gap filled with denatured muscle grafts. Clinical assessment after periods up to 150 days showed good sensory and motor recovery which correlated well with the histological findings. The muscle graft technique may be of value for the treatment of chronic nerve lesions in selected cases of leprosy.
Original languageEnglish
Pages (from-to)874-880
Number of pages7
JournalJournal of Bone and Joint Surgery - British Volume
Issue number5
Publication statusPublished - 1 Jan 1990

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